The in-vivo use of superparamagnetic iron oxide nanoparticles to detect inflammation elicits a cytokine response but does not aggravate experimental arthritis.

Date publication

mai 2015

Journal

PloS one

Auteurs

Membres identifiés du Cancéropôle Est :
Dr MAURIZI Lionel

Tous les auteurs :
Vermeij EA, Koenders MI, Bennink MB, Crowe LA, Maurizi L, Vallée JP, Hofmann H, van den Berg WB, van Lent PL, van de Loo FA

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25955417

Résumé

Superparamagnetic Iron Oxide Nanoparticles (SPION) are used in diagnostic imaging of a variety of different diseases. For such in-vivo application, an additional coating with a polymer, for example polyvinyl alcohol (PVA), is needed to stabilize the SPION and prevent aggregation. As the particles are foreign to the body, reaction against the SPION could occur. In this study we investigated the effects that SPION may have on experimental arthritis after intra-articular (i.a.) or intravenous (i.v.) injection.

Mots clés

Animals, Arthritis, Experimental, immunology, Cytokines, genetics, Ferric Compounds, metabolism, Injections, Intra-Articular, Injections, Intravenous, Magnetic Resonance Imaging, Magnetite Nanoparticles, administration & dosage, Mice, Polyvinyl Alcohol, chemistry

Référence

PLoS One. 2015 05 8;10(5):e0126687