Fiche publication
Date publication
décembre 2015
Journal
Environmental health perspectives
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MAURIZI Lionel
Tous les auteurs :
Grafmueller S, Manser P, Diener L, Diener PA, Maeder-Althaus X, Maurizi L, Jochum W, Krug HF, Buerki-Thurnherr T, von Mandach U, Wick P
Lien Pubmed
Résumé
Nanoparticle exposure in utero might not be a major concern yet, but it could become more important with the increasing application of nanomaterials in consumer and medical products. Several epidemiologic and in vitro studies have shown that nanoparticles can have potential toxic effects. However, nanoparticles also offer the opportunity to develop new therapeutic strategies to treat specifically either the pregnant mother or the fetus. Previous studies mainly addressed whether nanoparticles are able to cross the placental barrier. However, the transport mechanisms underlying nanoparticle translocation across the placenta are still unknown.
Mots clés
Female, Humans, In Vitro Techniques, Maternal-Fetal Exchange, Nanoparticles, Particle Size, Perfusion, Placenta, metabolism, Polystyrenes, pharmacokinetics, Pregnancy, Trophoblasts, metabolism
Référence
Environ Health Perspect. 2015 12;123(12):1280-6
