Fiche publication
Date publication
septembre 2016
Journal
Biologie aujourd'hui
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MONASSIER Laurent
Tous les auteurs :
Ayme-Dietrich E, Banas SM, Monassier L, Maroteaux L
Lien Pubmed
Résumé
Serotonin and bone-marrow-derived stem cells participate together in triggering pulmonary hypertension. Our work has shown that the absence of 5-HT2B receptors generates permanent changes in the composition of the blood and bone-marrow in the myeloid lineages, particularly in endothelial cell progenitors. The initial functions of 5-HT2B receptors in pulmonary arterial hypertension (PAH) are restricted to bone-marrow cells. They contribute to the differentiation/proliferation/mobilization of endothelial progenitor cells from the bone-marrow. Those bone-marrow-derived cells have a critical role in the development of pulmonary hypertension and pulmonary vascular remodeling. These data indicate that bone-marrow derived endothelial progenitors play a key role in the pathogenesis of PAH and suggest that interactions involving serotonin and bone morphogenic protein type 2 receptor (BMPR2) could take place at the level of the bone-marrow.
Mots clés
Animals, Bone Marrow, physiology, Bone Marrow Cells, physiology, Bone Morphogenetic Protein Receptors, Type II, physiology, Endothelial Cells, physiology, Humans, Hypertension, Pulmonary, etiology, Mice, Serotonin, physiology, Stem Cells, physiology
Référence
Biol Aujourdhui. 2016 09 30;210(2):79-88
