Fiche publication
Date publication
mars 2025
Journal
Frontiers in neuroscience
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MANDEL Jean-Louis
Tous les auteurs :
Courraud J, Quartier A, Drouot N, Zapata-Bodalo I, Gilet J, Benchoua A, Mandel JL, Piton A
Lien Pubmed
Résumé
Mutations in (DYRK1A) represent one of the most prevalent monogenic causes of neurodevelopmental disorders (NDDs), often associated with intellectual developmental disorder and autism spectrum disorder. DYRK1A encodes a dual-specificity kinase (tyrosine and serine/threonine) that plays a key role in various cellular processes and is a critical regulator of nervous system development.
Mots clés
DYRK1A, RNF114, cell proliferation, gene expression, human neural stem cells, interactome, neurodevelopmental disorders, p21/CDKN1A
Référence
Front Neurosci. 2025 03 13;19:1533253
