Fiche publication
Date publication
avril 2025
Journal
Trends in cell biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr TAVIAN Manuela
Tous les auteurs :
Randolph LN, Castiglioni C, Tavian M, Sturgeon CM, Ditadi A
Lien Pubmed
Résumé
The generation of blood cells during embryonic development involves a process resembling lineage reprogramming, where specialized cells within the vasculature become blood forming, or hemogenic. These hemogenic cells undergo rapid transcriptional and morphological changes as they appear to switch from an endothelial to blood identity. What controls this process and the exact nature of the hemogenic cells remains debated, with evidence supporting several hypotheses. In this opinion, we synthesize current knowledge and propose a model reconciling conflicting observations, integrating evolutionary and mechanistic insights into blood cell emergence.
Mots clés
endothelial cells, hemangioblast, hematopoietic development, hematopoietic stem cells, hemogenesis
Référence
Trends Cell Biol. 2025 04 10;:
