Primary cutaneous NUT adnexal carcinoma: morphologic, genetic and methylation analysis of seven new cases with comparison to extracutaneous NUT carcinoma and NUTM1-rearranged porocarcinoma.

Fiche publication

Date publication

mars 2025

Journal

Histopathology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CRIBIER Bernard

Tous les auteurs :
Legrand M, Louveau B, Osio A, Tallet A, Calonje E, Scoazec JY, de la Fouchardiere A, Tirode F, Von Deimling A, Busam K, Shah A, Flaman A, Jouenne F, Mourah S, Pissaloux D, Lantuejoul S, French CA, Goto K, Cribier B, Dehner CA, Alomari AK, Fletcher CD, Hanna J, Macagno N, Battistella M, Kervarrec T

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/40125640

Résumé

NUT carcinoma is a rare malignant neoplasm characterised by recurrent NUTM1 rearrangements, initially reported in the midline. Recently, 10 cases of cutaneous NUT carcinoma with adnexal differentiation harbouring BRD3::NUTM1, NSD3::NUTM1, BRD4::NUTM1 or BRD3::NUTM2B fusions have been reported. Accordingly, 'NUT adnexal carcinoma' (NAC) has been introduced as a provisional tumour entity to the fifth edition of the WHO Classification of Skin Tumours.