Fiche publication
Date publication
juillet 2019
Journal
Endocrine connections
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BENANI Alexandre
Tous les auteurs :
Prévost G, Picot M, Le Solliec MA, Arabo A, Berrahmoune H, El Mehdi M, Cherifi S, Benani A, Nédélec E, Gobet F, Brunel V, Leprince J, Lefebvre H, Anouar Y, Chartrel N
Lien Pubmed
Résumé
Recent studies performed in mice revealed that the neuropeptide 26RFa regulates glucose homeostasis by acting as an incretin and by increasing insulin sensitivity. However, in humans, an association between 26RFa and the regulation of glucose homeostasis is poorly documented. In this study, we have thus investigated in detail the distribution of 26RFa and its receptor, GPR103, in the gut and the pancreas, and determined the response of this peptidergic system to an oral glucose challenge in obese patients.
Mots clés
glucose homeostasis, gut, incretin, insulin, obesity, pancreas
Référence
Endocr Connect. 2019 07;8(7):941-951
