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Date publication
juin 2022
Journal
The Journal of organic chemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VILLETTE Claire
Tous les auteurs :
Moegle B, Hourtoule M, Gommenginger C, Belabbes A, Villette C, Elser D, Gaquerel E, Navrot N, Miesch L
Lien Pubmed
Résumé
A synthesis of new-to-nature aza-iridoids ynamides is presented. ZrCl proved to be the best acid to perform this transformation. Various ynamides were accommodated, and -iridoids could be obtained as well. Aza-iridoids were infiltrated into leaves of , an iridoid-producing plant species. High-resolution mass spectrometry coupled to computational metabolomic approaches was employed for the detection of aza-iridoid bioconversion products.
Mots clés
Iridoids, chemistry, Mass Spectrometry, Plant Leaves, Scrophularia, chemistry
Référence
J Org Chem. 2022 06 3;87(11):7229-7238
