Fiche publication
Date publication
octobre 2023
Journal
Neuroscience and biobehavioral reviews
Auteurs
Membres identifiés du Cancéropôle Est :
Dr YALCIN CHRISTMANN Ipek
Tous les auteurs :
Journée SH, Mathis VP, Fillinger C, Veinante P, Yalcin I
Lien Pubmed
Résumé
Over the past 20 years, clinical and preclinical studies point to the anterior cingulate cortex (ACC) as a site of interest for several neurological and psychiatric conditions. The ACC plays a critical role in emotion, autonomic regulation, pain processing, attention, memory and decision making. An increasing number of studies have demonstrated the involvement of the ACC in the emotional component of pain and its comorbidity with emotional disorders such as anxiety and depression. Thanks to the development of animal models combined with state-of-the-art technologies, we now have a better mechanistic understanding of the functions of the ACC. Hence, the primary aim of this review is to compile the most recent preclinical studies on the role of ACC in the emotional component and consequences of chronic pain. Herein, we thus thoroughly describe the pain-induced electrophysiological, molecular and anatomical alterations in the ACC and in its related circuits. Finally, we discuss the next steps that are needed to strengthen our understanding of the involvement of the ACC in emotional and pain processing.
Mots clés
ACC, Anterior cingulate cortex, Anxiety, Area 24a, Area 24b, Area 32, Aversion, Chronic pain, Circuits, Depression, Pain, Rodent models
Référence
Neurosci Biobehav Rev. 2023 10;153:105362
