H3K9ac of TGFβRI in human umbilical cord: a potential biomarker for evaluating cartilage differentiation and susceptibility to osteoarthritis via a two-step strategy.

Fiche publication

Date publication

mars 2021

Journal

Stem cell research & therapy

Auteurs

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/33663609

Résumé

Epidemiological investigation and our previous reports indicated that osteoarthritis had a fetal origin and was closely associated with intrauterine growth retardation (IUGR). Human Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) could be programmable to "remember" early-life stimuli. Here, we aimed to explore an early-warning biomarker of fetal-originated adult osteoarthritis in the WJ-MSCs.