Pr SAVARY Stéphane

Fiche personne

Coordonnées

CSGA
9E bd Jeanne d'Arc
21000 DIJON

Territoire

Bourgogne

Statut

Enseignant-Chercheur

Affiliation

Université Bourgogne Europe (UBE)

Centre des sciences du goût et de l'alimentation (CSGA)

Équipes/plateformes

Equipe "Neurobiologie des comportements alimentaires (NeuroFeed)"

Publications

Peroxisomes and the nervous system: progress and challenges in neuroinflammation and cell-specific functions.

Di Cara F, Savary S

Front Mol Neurosci. 2026 02 11;19:1745086

Analytical subcellular fractionation of microglial BV-2 cells with peroxisomal beta-oxidation defect.

Tahri-Joutey M, Hamer I, Tevel V, Raas Q, Gondcaille C, Trompier D, Kebbaj RE, Ménétrier F, Latruffe N, Lizard G, Nasser B, Savary S, Jadot M, Cherkaoui-Malki M, Andreoletti P

Histochem Cell Biol. 2025 04 14;163(1):44

Ribes nigrum leaf extract downregulates pro-inflammatory gene expression and regulates redox balance in microglial cells.

Minasyan A, Pires V, Gondcaille C, Ginovyan M, Mróz M, Savary S, Cherkaoui-Malki M, Kusznierewicz B, Bartoszek A, Andreoletti P, Sahakyan N

BMC Complement Med Ther. 2025 02 12;25(1):49

Impaired peroxisomal beta-oxidation in microglia triggers oxidative stress and impacts neurons and oligodendrocytes.

Tawbeh A, Gondcaille C, Saih FE, Raas Q, Loichot D, Hamon Y, Keime C, Benani A, Di Cara F, Cherkaoui-Malki M, Andreoletti P, Savary S

Front Mol Neurosci. 2025 01 30;18:1542938

Peroxisome deficiency underlies failures in hepatic immune cell development and antigen presentation in a severe Zellweger disease model.

Parsons BD, Medina-Luna D, Scur M, Pinelli M, Gamage GS, Chilvers RA, Hamon Y, Ahmed IHI, Savary S, Makrigiannis AP, Braverman NE, Rodriguez-Alcazar JF, Latz E, Karakach TK, Di Cara F

Cell Rep. 2024 02 27;43(2):113744

Microgliosis: a double-edged sword in the control of food intake.

Salvi J, Andreoletti P, Audinat E, Balland E, Ben Fradj S, Cherkaoui-Malki M, Heurtaux T, Liénard F, Nédélec E, Rovère C, Savary S, Véjux A, Trompier D, Benani A

FEBS J. 2024 02;291(4):615-631

Immune response of BV-2 microglial cells is impacted by peroxisomal beta-oxidation.

Tawbeh A, Raas Q, Tahri-Joutey M, Keime C, Kaiser R, Trompier D, Nasser B, Bellanger E, Dessard M, Hamon Y, Benani A, Di Cara F, Cunha Alves T, Berger J, Weinhofer I, Mandard S, Cherkaoui-Malki M, Andreoletti P, Gondcaille C, Savary S

Front Mol Neurosci. 2023 12 18;16:1299314

Peroxisomal defects in microglial cells induce a disease-associated microglial signature.

Raas Q, Tawbeh A, Tahri-Joutey M, Gondcaille C, Keime C, Kaiser R, Trompier D, Nasser B, Leoni V, Bellanger E, Boussand M, Hamon Y, Benani A, Di Cara F, Truntzer C, Cherkaoui-Malki M, Andreoletti P, Savary S

Front Mol Neurosci. 2023 04 17;16:1170313

Two Argan Oil Phytosterols, Schottenol and Spinasterol, Attenuate Oxidative Stress and Restore LPS-Dysregulated Peroxisomal Functions in and Wild-Type BV-2 Microglial Cells.

Essadek S, Gondcaille C, Savary S, Samadi M, Vamecq J, Lizard G, Kebbaj RE, Latruffe N, Benani A, Nasser B, Cherkaoui-Malki M, Andreoletti P

Antioxidants (Basel). 2023 01 11;12(1):

The peroxisome: an up-and-coming organelle in immunometabolism.

Di Cara F, Savary S, Kovacs WJ, Kim P, Rachubinski RA

Trends Cell Biol. 2023 01;33(1):70-86

Protective Effect of Nopal Cactus () Seed Oil against Short-Term Lipopolysaccharides-Induced Inflammation and Peroxisomal Functions Dysregulation in Mouse Brain and Liver.

Tahri-Joutey M, Saih FE, El Kebbaj R, Gondcaille C, Vamecq J, Latruffe N, Lizard G, Savary S, Nasser B, Cherkaoui-Malki M, Andreoletti P

Int J Mol Sci. 2022 10 6;23(19):

Effects of a Short-Term Lipopolysaccharides Challenge on Mouse Brain and Liver Peroxisomal Antioxidant and β-oxidative Functions: Protective Action of Argan Oil.

Essadek S, Bouchab H, El Kebbaj R, Gondcaille C, El Kamouni S, Savary S, Vamecq J, Essamadi A, Cherkaoui-Malki M, Nasser B, Andreoletti P

Pharmaceuticals (Basel). 2022 04 12;15(4):

Peroxisomal ABC Transporters: An Update.

Tawbeh A, Gondcaille C, Trompier D, Savary S

Int J Mol Sci. 2021 06 5;22(11):

Do ABC transporters regulate plasma membrane organization?

Wu A, Wojtowicz K, Savary S, Hamon Y, Trombik T

Cell Mol Biol Lett. 2020 07 6;25:37

Peroxisomes in Immune Response and Inflammation.

Di Cara F, Andreoletti P, Trompier D, Vejux A, Bülow MH, Sellin J, Lizard G, Cherkaoui-Malki M, Savary S

Int J Mol Sci. 2019 Aug 8;20(16):

CRISPR/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2 cells: Novel microglial models for X-linked Adrenoleukodystrophy.

Raas Q, Gondcaille C, Hamon Y, Leoni V, Caccia C, Ménétrier F, Lizard G, Trompier D, Savary S

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Feb 12;:

A microglial cell model for acyl-CoA oxidase 1 deficiency.

Raas Q, Saih FE, Gondcaille C, Trompier D, Hamon Y, Leoni V, Caccia C, Nasser B, Jadot M, Ménétrier F, Lizard G, Cherkaoui-Malki M, Andreoletti P, Savary S

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct 9;:

Predictive Structure and Topology of Peroxisomal ATP-Binding Cassette (ABC) Transporters.

Andreoletti P, Raas Q, Gondcaille C, Cherkaoui-Malki M, Trompier D, Savary S

Int J Mol Sci. 2017 07 22;18(7):

Brain-derived neurotrophic factor of the cerebral microvasculature: a forgotten and nitric oxide-dependent contributor of brain-derived neurotrophic factor in the brain.

Monnier A, Prigent-Tessier A, Quirié A, Bertrand N, Savary S, Gondcaille C, Garnier P, Demougeot C, Marie C

Acta Physiol (Oxf). 2017 04;219(4):790-802

Peroxisomal ATP-binding cassette transporters form mainly tetramers.

Geillon F, Gondcaille C, Raas Q, Dias AM, Pecqueur D, Truntzer C, Lucchi G, Ducoroy P, Falson P, Savary S, Trompier D

J. Biol. Chem.. 2017 Mar;:

Flow Cytometric Analysis of the Expression Pattern of Peroxisomal Proteins, Abcd1, Abcd2, and Abcd3 in BV-2 Murine Microglial Cells.

Debbabi M, Nury T, Helali I, Karym EM, Geillon F, Gondcaille C, Trompier D, Najid A, Terreau S, Bezine M, Zarrouk A, Vejux A, Andreoletti P, Cherkaoui-Malki M, Savary S, Lizard G

Methods Mol. Biol.. 2017 ;1595:257-265

Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes.

Zarrouk A, Nury T, Karym EM, Vejux A, Sghaier R, Gondcaille C, Andreoletti P, Trompier D, Savary S, Cherkaoui-Malki M, Debbabi M, Fromont A, Riedinger JM, Moreau T, Lizard G

J. Steroid Biochem. Mol. Biol.. 2016 Feb;:

Structure-function analysis of peroxisomal ATP-binding cassette transporters using chimeric dimers.

Geillon F, Gondcaille C, Charbonnier S, Van Roermund CW, Lopez TE, Dias AM, Pais de Barros JP, Arnould C, Wanders RJ, Trompier D, Savary S

J Biol Chem. 2014 08 29;289(35):24511-20

Regulation of the adrenoleukodystrophy-related gene (ABCD2): focus on oxysterols and LXR antagonists.

Trompier D, Gondcaille C, Lizard G, Savary S

Biochem Biophys Res Commun. 2014 Apr 11;446(3):651-5

Brain peroxisomes.

Trompier D, Vejux A, Zarrouk A, Gondcaille C, Geillon F, Nury T, Savary S, Lizard G

Biochimie. 2014 Mar;98:102-10

LXR antagonists induce ABCD2 expression.

Gondcaille C, Genin EC, Lopez TE, Dias AM, Geillon F, Andreoletti P, Cherkaoui-Malki M, Nury T, Lizard G, Weinhofer I, Berger J, Kase ET, Trompier D, Savary S

Biochim Biophys Acta. 2014 Feb;1841(2):259-66.

Fatty acids - induced lipotoxicity and inflammation.

Savary S, Trompier D, Andreoletti P, Le Borgne F, Demarquoy J, Lizard G

Curr Drug Metab. 2012 Dec;13(10):1358-70.

[Peroxisomal ABC transporters and X-linked adrenoleukodystrophy].

Geillon F, Trompier D, Gondcaille C, Lizard G, Savary S

Med Sci (Paris). 2012 Dec;28(12):1087-94

Evidence of oxidative stress in very long chain fatty acid--treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins.

Baarine M, Andreoletti P, Athias A, Nury T, Zarrouk A, Ragot K, Vejux A, Riedinger JM, Kattan Z, Bessede G, Trompier D, Savary S, Cherkaoui-Malki M, Lizard G

Neuroscience. 2012 Jun 28;213:1-18