Dr DE ISLA Natalia

Optimized GMP-grade Wharton's jelly's mesenchymal stromal cells manufacturing and administration protocol for Graft versus Host disease prevention.

Pochon C, Perouf R, Notarantonio AB, Bertrand A, Charif N, Marcelo CB, Fouquet G, Cauchois G, Bensoussan D, Moulin D, Pagliuca S, de Isla N, Sartelet H, D'Aveni M, Rubio MT

Curr Res Transl Med. 2025 09 10;73(4):103543

Biomaterial-Based Nucleic Acid Delivery Systems for In Situ Tissue Engineering and Regenerative Medicine.

Wu QX, De Isla N, Zhang L

Int J Mol Sci. 2025 07 30;26(15):

Highly immunosuppressive myeloid cells correlate with early relapse after allogeneic stem cell transplantation.

Notarantonio AB, Bertrand A, Piucco R, Fievet G, Sartelet H, Boulangé L, de Isla N, De Carvalho Bittencourt M, Hergalant S, Rubio MT, D'Aveni M

Exp Hematol Oncol. 2024 05 11;13(1):50

Scale-Up of Academic Mesenchymal Stromal Cell Production.

Laroye C, Gauthier M, Morello J, Charif N, Cannard VL, Bonnet C, Lozniewski A, Tchirkov A, De Isla N, Decot V, Reppel L, Bensoussan D

J Clin Med. 2023 06 30;12(13):

Impact of microcarrier concentration on mesenchymal stem cell growth and death: Experiments and modeling.

Maillot C, De Isla N, Loubiere C, Toye D, Olmos E

Biotechnol Bioeng. 2022 09 16;:

Secretome of Mesenchymal Stem Cells from Consecutive Hypoxic Cultures Promotes Resolution of Lung Inflammation by Reprogramming Anti-Inflammatory Macrophages.

Xu Z, Lin L, Fan Y, Huselstein C, De Isla N, He X, Chen Y, Li Y

Int J Mol Sci. 2022 04 14;23(8):

A new perfusion mode of culture for WJ-MSCs expansion in a stirred and online monitored bioreactor.

Sion C, Ghannoum D, Ebel B, Gallo F, de Isla N, Guedon E, Chevalot I, Olmos E

Biotechnol Bioeng. 2021 11;118(11):4453-4464

Quality by design to define critical process parameters for mesenchymal stem cell expansion.

Maillot C, Sion C, De Isla N, Toye D, Olmos E

Biotechnol Adv. 2021 05 5;50:107765

Characterization of Bone Marrow and Wharton's Jelly Mesenchymal Stromal Cells Response on Multilayer Braided Silk and Silk/PLCL Scaffolds for Ligament Tissue Engineering.

Liu X, Baldit A, de Brosses E, Velard F, Cauchois G, Chen Y, Wang X, de Isla N, Laurent C

Polymers (Basel). 2020 Sep 22;12(9):

Impact of the type of microcarrier and agitation modes on the expansion performances of mesenchymal stem cells derived from umbilical cord.

Loubière C, Sion C, De Isla N, Reppel L, Guedon E, Chevalot I, Olmos E

Biotechnol Prog. 2019 11;35(6):e2887

Mesenchymal stem cell interacted with PLCL braided scaffold coated with poly-l-lysine/hyaluronic acid for ligament tissue engineering.

Liu X, Laurent C, Du Q, Targa L, Cauchois G, Chen Y, Wang X, de Isla N

J Biomed Mater Res A. 2018 12;106(12):3042-3052

Laser photobiomodulation in pressure ulcer healing of human diabetic patients: gene expression analysis of inflammatory biochemical markers.

Ruh AC, Frigo L, Cavalcanti MFXB, Svidnicki P, Vicari VN, Lopes-Martins RAB, Leal Junior ECP, De Isla N, Diomede F, Trubiani O, Favero GM

Lasers Med Sci. 2018 01;33(1):165-171

MyD88/ERK/NFkB pathways and pro-inflammatory cytokines release in periodontal ligament stem cells stimulated by Porphyromonas gingivalis.

Diomede F, Zingariello M, Cavalcanti MFXB, Merciaro I, Pizzicannella J, De Isla N, Caputi S, Ballerini P, Trubiani O

Eur J Histochem. 2017 05 24;61(2):2791

Mechanical stimulations on human Bone Marrow Mesenchymal Stem Cells enhance cells differentiation in a 3D layered scaffold.

Schiavi J, Reppel L, Charif N, de Isla N, Mainard D, Benkirane-Jessel N, Stoltz JF, Rahouadj R, Huselstein C

J Tissue Eng Regen Med. 2017 May;:

Aging of bone marrow mesenchymal stromal/stem cells: Implications on autologous regenerative medicine.

Charif N, Li YY, Targa L, Zhang L, Ye JS, Li YP, Stoltz JF, Han HZ, de Isla N

Biomed Mater Eng. 2017 ;28(s1):S57-S63

Mechanobiology of mesenchymal stem cells: Which interest for cell-based treatment?

Huselstein C, Rahouadj R, de Isla N, Bensoussan D, Stoltz JF, Li YP

Biomed Mater Eng. 2017 ;28(s1):S47-S56

Organ reconstruction: Dream or reality for the future.

Stoltz JF, Zhang L, Ye JS, De Isla N

Biomed Mater Eng. 2017 ;28(s1):S121-S127

Rat BMSC infusion was unable to ameliorate inflammatory injuries in tissues of mice with LPS-induced endotoxemia.

Xie X, Liu H, Wu J, Chen Y, Yu Z, De Isla N, He X, Li Y

Biomed Mater Eng. 2017 ;28(s1):S129-S138

Research progress in liver tissue engineering.

Zhang L, Guan Z, Ye JS, Yin YF, Stoltz JF, de Isla N

Biomed Mater Eng. 2017 ;28(s1):S113-S119

Comparative Study of the Physiotherapeutic and Drug Protocol and Low-Level Laser Irradiation in the Treatment of Pain Associated with Temporomandibular Dysfunction.

Cavalcanti MF, Silva UH, Leal-Junior EC, Lopes-Martins RA, Marcos RL, Pallotta RC, Diomede F, Trubiani O, De Isla N, Frigo L

Photomed Laser Surg. 2016 12;34(12):652-656

Stem cells and vascular regenerative medicine: A mini review.

Stoltz JF, Bensoussan D, De Isla N, Zhang L, Han Z, Magdalou J, Huselstein C, Ye JS, Leballe B, Decot V, Reppel L

Clin. Hemorheol. Microcirc.. 2016 ;64(4):613-633

Evaluation of the Proliferative Effects Induced by Low-Level Laser Therapy in Bone Marrow Stem Cell Culture.

Cavalcanti MF, Maria DA, de Isla N, Leal-Junior EC, Joensen J, Bjordal JM, Lopes-Martins RA, Diomede F, Trubiani O, Frigo L

Photomed Laser Surg. 2015 12;33(12):610-6

Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes.

Ye JS, Su XS, Stoltz JF, de Isla N, Zhang L

Cell Prolif.. 2015 Apr;48(2):157-65

An approach to preparing decellularized whole liver organ scaffold in rat.

Ye JS, Stoltz JF, de Isla N, Liu Y, Yin YF, Zhang L

Biomed Mater Eng. 2015 ;25(1 Suppl):159-66

Application potential of mesenchymal stem cells derived from Wharton's jelly in liver tissue engineering.

Zhang L, Zhao YH, Guan Z, Ye JS, de Isla N, Stoltz JF

Biomed Mater Eng. 2015 ;25(1 Suppl):137-43

Stem cells and applications: a survey.

Stoltz JF, Bensoussan D, Zhang L, Decot V, De Isla N, Li YP, Huselstein C, Benkirane-Jessel N, Li N, Reppel L, He Y, Li YY

Biomed Mater Eng. 2015;25(1 Suppl):3-26

Stem Cells and Regenerative Medicine: Myth or Reality of the 21th Century.

Stoltz JF, de Isla N, Li YP, Bensoussan D, Zhang L, Huselstein C, Chen Y, Decot V, Magdalou J, Li N, Reppel L, He Y

Stem Cells Int. 2015;2015:734731

Toward an understanding of mechanism of aging-induced oxidative stress in human mesenchymal stem cells.

Benameur L, Charif N, Li Y, Stoltz JF, de Isla N

Biomed Mater Eng. 2015 ;25(1 Suppl):41-6

Donor's age dependent proliferation decrease of human bone marrow mesenchymal stem cells is linked to diminished clonogenicity.

Li Y, Charif N, Mainard D, Bensoussan D, Stoltz JF, de Isla N

Biomed Mater Eng. 2014;24(1 Suppl):47-52

The Nebivolol action on vascular tone is dependent on actin cytoskeleton polymerization and Rho-A activity into ECs and SMCs.

Kadi A, de Isla N, Moby V, Lacolley P, Labrude P, Stoltz JF, Menu P

Clin. Hemorheol. Microcirc.. 2014 ;56(3):231-46

Hydroxyapatite incorporated into collagen gels for mesenchymal stem cell culture.

Laydi F, Rahouadj R, Cauchois G, Stoltz JF, de Isla N

Biomed Mater Eng. 2013 ;23(4):311-5

Human stem cells and articular cartilage tissue engineering.

Stoltz JF, Huselstein C, Schiavi J, Li YY, Bensoussan D, Decot V, De Isla N

Curr Pharm Biotechnol. 2012 Dec;13(15):2682-91.

Introduction to regenerative medicine and tissue engineering.

Stoltz JF, Decot V, Huseltein C, He X, Zhang L, Magdalou J, Li YP, Menu P, Li N, Wang YY, de Isla N, Bensoussan D

Biomed Mater Eng. 2012;22(1-3):3-16

Research on stem cells as candidates to be differentiated into hepatocytes.

Zhang L, Ye JS, Decot V, Stoltz JF, de Isla N

Biomed Mater Eng. 2012 ;22(1-3):105-11

SHG as a new modality for large field of view imaging to monitor tissue collagen network.

Dumas D, Hupont S, Huselstein C, de Isla N, Rousseau M, Werkmeister E, Magdalou J, Menu P, Stoltz JF

Biomed Mater Eng. 2012 ;22(1-3):159-62

Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status.

Basciano L, Nemos C, Foliguet B, de Isla N, de Carvalho M, Tran N, Dalloul A

BMC Cell Biol.. 2011 Mar 30;12:12

Aligned poly(L-lactic-co-e-caprolactone) electrospun microfibers and knitted structure: a novel composite scaffold for ligament tissue engineering.

Vaquette C, Kahn C, Frochot C, Nouvel C, Six JL, De Isla N, Luo LH, Cooper-White J, Rahouadj R, Wang X

J Biomed Mater Res A. 2010 Sep 15;94(4):1270-82.

In vitro initial expansion of mesenchymal stem cells is influenced by the culture parameters used in the isolation process.

Chen HH, Decot V, Ouyang JP, Stoltz JF, Bensoussan D, de Isla NG

Biomed Mater Eng. 2009;19(4-5):301-9.

Effect of alginate culture and mechanical stimulation on cartilaginous matrix synthesis of rat dedifferentiated chondrocytes.

Wang Y, de Isla N, Huselstein C, Wang B, Netter P, Stoltz JF, Muller S

Biomed Mater Eng. 2008 ;18(1 Suppl):S47-54

In vitro effects of diacerein on NO production by chondrocytes in response to proinflammatory mediators.

de Isla NG, Mainard D, Muller S, Stoltz JF

Biomed Mater Eng. 2008;18(1 Suppl):S99-104.

In vitro inhibition of IL-1beta catabolic effects on cartilage: a mechanism involved on diacerein anti-OA properties.

de Isla NG, Stoltz JF

Biorheology. 2008 ;45(3-4):433-8

Influences of construct properties on the proliferation and matrix synthesis of dedifferentiated chondrocytes cultured in alginate gel.

Wang Y, De Isla N, Decot V, Marchal L, Cauchois G, Huselstein C, Muller S, Wang BH, Netter P, Stoltz JF

Biorheology. 2008;45(3-4):527-38.

Potential relation between cytoskeleton reorganization and e-NOS activity in sheared endothelial cells (Effect of rate and time of exposure).

Kadi A, de Isla N, Lacolley P, Stoltz JF, Menu P

Clin. Hemorheol. Microcirc.. 2007 ;37(1-2):131-40

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