Mr HUMBERT Nicolas

Fiche personne

Coordonnées

Laboratoire de Bioimagerie et Pathologies
Faculté de Pharmacie
74 route du Rhin
CS 60024
67401 ILLKIRCH

03 68 85 41 56

Territoire

Alsace

Statut

Ingénieur/Technicien

Affiliation

Laboratoire de bioimagerie et pathologies UMR CNRS 7021 (LBP)

Équipes/plateformes

UMR 7021 - Equipe "Biophotonique des interactions moléculaires et cellulaires - BIMC"

Plateforme de spectroscopie et de synthèse peptidique

Publications

Sorting of lysosomal enzyme and autophagy are regulated by the GGA1-induced TGN lipid scrambling.

Takahashi K, Tomishige N, Abe M, Šolinc G, Rae J, Yamaji T, Przybilla F, Richert L, Humbert N, Uemura T, Wollert T, Waguri S, Hanada K, Sako Y, Anderluh G, Parton RG, Mély Y, Tomasetto C, Alpy F, Kobayashi T

Sci Adv. 2026 08 28;12(35):eaec4519

Probing the Structure and Dynamics of Telomeric G-Quadruplexes with Thienoguanosine, a Fluorescent Analogue of Guanosine.

Singh P, Mukherjee D, Hanser F, Tkach O, Humbert N, Avendano Avila C, Ciaco S, Martinez-Fernandez L, Bansal S, Kanj S, Bombarda E, Bourderioux A, Dziuba D, Tor Y, Improta R, Mori M, Heddi B, Mély Y

ACS Chem Biol. 2026 05 7;:

Gangliosides and Membrane Microdomains.

Murate M, Yokoyama N, Tomishige N, Humbert N, Richert L, Mély Y, Iwabuchi K, Kobayashi T

Methods Mol Biol. 2026 ;3035:369-383

Decoding the base flipping mechanism of the SET- and RING-associated (SRA) domain of the epigenetic UHRF1 protein.

Mukherjee D, Ciaco S, Martinez-Fernandez L, Gavvala K, Bombarda E, Bourdérioux A, Dziuba D, Hanser F, Humbert N, Javed A, Mousli M, Singh P, Tor Y, Improta R, Mori M, Mély Y

Nucleic Acids Res. 2025 09 5;53(17):

Exploring excited-state proton transfer reactions in isothiazologuanosine, an isofunctional fluorescent analogue of guanosine.

Tkach O, Martinez-Fernandez L, Ruiz-Lera AE, Humbert N, Richert L, Dziuba D, Bombarda E, Bourderioux A, Hanser F, Didier P, Tor Y, Improta R, Léonard J, Mély Y

Phys Chem Chem Phys. 2025 09 3;:

Synthesis and Pharmacological Characterization of Fluorescent Ligands Targeting the Angiotensin II Receptors Derived from Agonists, β-Arrestin-Biased Agonists, and Antagonists.

Delaitre C, Boisbrun M, Acherar S, Dias A, Kleinclauss A, Achard M, Colin M, Nguyen TM, Humbert N, Chmeis K, Martinez KL, Gilles N, Robin P, Lecat S, Dupuis F

J Med Chem. 2024 11 11;:

Rational Design of Cyanine-Based Fluorogenic Dimers to Reduce Nonspecific Interactions with Albumin and Lipid Bilayers: Application to Highly Sensitive Imaging of GPCRs in Living Cells.

Berthomé Y, Gerber J, Hanser F, Riché S, Humbert N, Valencia C, Villa P, Karpenko J, Florès O, Bonnet D

Bioconjug Chem. 2024 07 9;:

Integrase-LEDGF/p75 complex triggers the formation of biomolecular condensates that modulate HIV-1 integration efficiency in vitro.

Batisse C, Lapaillerie D, Humbert N, Real E, Zhu R, Mély Y, Parissi V, Ruff M, Batisse J

J Biol Chem. 2024 05 16;:107374

The Arabidopsis tDR Ala forms G-quadruplex structures that can be unwound by the DExH1 DEA(D/H)-box RNA helicase.

Chery M, Berrissou C, Humbert N, Hummel G, Mely Y, Salinas-Giegé T, Drouard L

Plant J. 2023 12 19;:

Upstream of N-Ras (Unr/CSDE1) Interacts with NCp7 and Gag, Modulating HIV-1 IRES-Mediated Translation Initiation.

Taha N, Zgheib S, Sharma KK, Humbert N, Boutant E, Didier P, Mély Y, Real E

Viruses. 2022 08 17;14(8):

Kinetics of protein-assisted nucleic acid interconversion monitored by transient time resolved fluorescence in microfluidic droplets.

Grytsyk N, Cianfarani D, Crégut O, Richert L, Boudier C, Humbert N, Didier P, Mély Y, Léonard J

Nucleic Acids Res. 2021 Aug 27;:

The HIV-1 nucleocapsid chaperone protein forms locally compacted globules on long double-stranded DNA.

Jiang K, Humbert N, K K S, Rouzina I, Mely Y, Westerlund F

Nucleic Acids Res. 2021 Apr 19;:

The nucleic acid chaperone activity of the HIV-1 Gag polyprotein is boosted by its cellular partner RPL7: a kinetic study.

Karnib H, Nadeem MF, Humbert N, Sharma KK, Grytsyk N, Tisné C, Boutant E, Lequeu T, Réal E, Boudier C, de Rocquigny H, Mély Y

Nucleic Acids Res.. 2020 Aug 14;:

A Class of Potent Inhibitors of the HIV-1 Nucleocapsid Protein Based on Aminopyrrolic Scaffolds.

Ciaco S, Humbert N, Real E, Boudier C, Francesconi O, Roelens S, Nativi C, Seguin-Devaux C, Mori M, Mély Y

ACS Med Chem Lett. 2020 May 14;11(5):698-705

(Thia)calixarenephosphonic acids as potent inhibitors of the nucleic acid chaperone activity of the HIV-1 nucleocapsid protein with a new binding mode and multi-target antiviral activity.

Humbert N, Kovalenko L, Saladini F, Giannini A, Pires M, Botzanowski T, Cherenok S, Boudier C, Sharma KK, Real E, Zaporozhets OA, Cianférani S, Seguin-Devaux C, Poggialini F, Botta M, Zazzi M, Kalchenko VI, Mori M, Mély Y

ACS Infect Dis. 2020 Feb 11;:

Formation of tubules and helical ribbons by ceramide phosphoethanolamine-containing membranes.

Inaba T, Murate M, Tomishige N, Lee YF, Hullin-Matsuda F, Pollet B, Humbert N, Mély Y, Sako Y, Greimel P, Kobayashi T

Sci Rep. 2019 Apr 9;9(1):5812

Annealing of ssDNA and compaction of dsDNA by the HIV-1 nucleocapsid and Gag proteins visualized using nanofluidic channels.

Jiang K, Humbert N, Kk S, Lequeu T, Lin YL, Mely Y, Westerlund F

Q. Rev. Biophys.. 2019 Jan;52:e2

HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry.

Pham VV, Salguero C, Khan SN, Meagher JL, Brown WC, Humbert N, de Rocquigny H, Smith JL, D'Souza VM

Nat Commun. 2018 10 15;9(1):4266

Rationally Designed Peptides as Efficient Inhibitors of Nucleic Acid Chaperone Activity of HIV-1 Nucleocapsid Protein.

Shvadchak V, Zgheib S, Basta B, Humbert N, Langedijk J, Morris MC, Ciaco S, Maskri O, Darlix JL, Mauffret O, Fossé P, Réal E, Mély Y

Biochemistry. 2018 Jul 18;:

Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains.

Mori M, Kovalenko L, Malancona S, Saladini F, De Forni D, Pires M, Humbert N, Real E, Botzanowski T, Cianférani S, Giannini A, Dasso Lang MC, Cugia G, Poddesu B, Lori F, Zazzi M, Harper S, Summa V, Mely Y, Botta M

ACS Chem. Biol.. 2018 01 19;13(1):253-266

A toolbox of chromones and quinolones for measuring a wide range of ATP concentrations.

Pivovarenko VG, Bugera O, Humbert N, Klymchenko AS, Mély Y

Chemistry. 2017 Jul;:

Oxyluciferin Derivatives: A Toolbox of Environment-Sensitive Fluorescence Probes for Molecular and Cellular Applications.

Ghose A, Maltsev OV, Humbert N, Hintermann L, Arntz Y, Naumov P, Mély Y, Didier P

J Phys Chem B. 2017 Feb;121(7):1566-1575

Fluorescence correlation spectroscopy as a sensitive and useful tool for revealing potential overlaps between the epitopes of monoclonal antibodies on viral particles.

Richert L, Humbert N, Larquet E, Girerd-Chambaz Y, Manin C, Ronzon F, Mély Y

MAbs. 2016 Oct;8(7):1235-1244

Convenient Access to Fluorescent Probes by Chemoselective Acylation of Hydrazinopeptides: Application to the Synthesis of the First Far-Red Ligand for Apelin Receptor Imaging.

Margathe JF, Iturrioz X, Regenass P, Karpenko IA, Humbert N, de Rocquigny H, Hibert M, Llorens-Cortes C, Bonnet D

Chemistry. 2016 Jan;22(4):1399-405

Site-Selective Monitoring of the Interaction of the SRA Domain of UHRF1 with Target DNA Sequences Labeled with 2-Aminopurine.

Greiner VJ, Kovalenko L, Humbert N, Richert L, Birck C, Ruff M, Zaporozhets OA, Dhe-Paganon S, Bronner C, Mely Y

Biochemistry. 2015 Sep 23.

Functional and structural characterization of 2-amino-4-phenylthiazole inhibitors of the HIV-1 nucleocapsid protein with antiviral activity.

Mori M, Nucci A, Lang MC, Humbert N, Boudier C, Debaene F, Sanglier-Cianferani S, Catala M, Schult-Dietrich P, Dietrich U, Tisne C, Mely Y, Botta M

ACS Chem Biol. 2014 Sep 19;9(9):1950-5

A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions.

Vercruysse T, Basta B, Dehaen W, Humbert N, Balzarini J, Debaene F, Sanglier-Cianferani S, Pannecouque C, Mely Y, Daelemans D

Retrovirology. 2012 Nov 12;9:95

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