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Publications
Differentially expressed fusogens specify myocyte states to drive myogenesis.
Nahlé S, Javed A, Joumier L, Kherdjemil Y, Sitolle J, Khetchoumian K, Parekh Y, Krezel W, Malleshaiah M, Le Grand F, Cayouette M, Côté JF
Development. 2025 09 17;:
Retinoid X Receptor Alpha Overexpression Protects Retinal Ganglion Cells and Modulates Inflammatory Response in Experimental Glaucoma.
Chitranshi N, Basavarajappa D, Palanivel V, Parrilla GE, Gupta V, Paulo JA, Salkar A, Mirzaei M, Koronyo-Hamaoui M, Krezel W, Graham SL, Gupta VK
Mol Ther. 2025 08 27;:
Vitamin A5: Evidence, Definitions, Gaps, and Future Directions.
Bohn T, Rohn S, Böhm V, Despotovic M, de Lera AR, Krezel W, Kucuk O, Bánáti D, Rühl R
Nutrients. 2025 07 14;17(14):
Compromised retinoic acid receptor beta expression accelerates the onset of motor, cellular and molecular abnormalities in a mouse model of Huntington's disease.
Zinter N, Ye T, Semaan H, Fraulob V, Plassard D, Krezel W
Neurobiol Dis. 2025 05 8;:106943
Retinoid X receptor agonist 9CDHRA mitigates retinal ganglion cell apoptosis and neuroinflammation in a mouse model of glaucoma.
Basavarajappa D, Chitranshi N, Oddin Mirshahvaladi SS, Gupta VB, Palanivel V, Parrilla GE, Salkar A, Mirzaei M, Komáromy AM, Krezel W, Graham SL, Gupta V
FASEB J. 2025 03 31;39(6):e70465
Intrinsic retinoic acid synthesis is required for oligodendrocyte progenitor expansion during CNS remyelination.
Nanescu SE, Wathieu NM, Rosko L, Cha DS, Kumar MN, Olszewski RT, Reger J, Baydyuk M, Dua AN, Krezel W, Zujovic V, Huang JK
Front Cell Neurosci. 2025 02 24;19:1550139
RLS-associated MEIS transcription factors control distinct processes in human neural stem cells.
Kittke V, Zhao C, Lam DD, Harrer P, Krezel W, Schormair B, Oexle K, Winkelmann J
Sci Rep. 2024 11 22;14(1):28986
Retinoids Molecular Probes by Late-stage Azide Insertion - Functional Tools to Decrypt Retinoid Metabolism.
Coulleray J, Kindler A, Rima M, Cahuzac H, Rochel N, Chaubet G, Krezel W, Wagner A
Chembiochem. 2024 08 2;:e202300689
Defining a vitamin A5/X specific deficiency - vitamin A5/X as a critical dietary factor for mental health.
Bánáti D, Hellman-Regen J, Mack I, Young HA, Benton D, Eggersdorfer M, Rohn S, Dulińska-Litewka J, Krężel W, Rühl R
Int J Vitam Nutr Res. 2024 06;94(5-6):443-475
Tamoxifen exerts direct and microglia-mediated effects preventing neuroinflammatory changes in the adult mouse hippocampal neurogenic niche.
Crisci I, Bonzano S, Nicolas Z, Dallorto E, Peretto P, Krezel W, De Marchis S
Glia. 2024 03 21;:
Identification of Greb1l as a genetic determinant of crisscross heart in mice showing torsion of the heart tube by shortage of progenitor cells.
Bernheim S, Borgel A, Le Garrec JF, Perthame E, Desgrange A, Michel C, Guillemot L, Sart S, Baroud CN, Krezel W, Raimondi F, Bonnet D, Zaffran S, Houyel L, Meilhac SM
Dev Cell. 2023 10 13;:
Neuro- and Cardiovascular Activities of Snake Venom.
Sahyoun C, Krezel W, Mattei C, Sabatier JM, Legros C, Fajloun Z, Rima M
Biology (Basel). 2022 06 9;11(6):
Retinoic acid receptor beta protects striatopallidal medium spiny neurons from mitochondrial dysfunction and neurodegeneration.
Ciancia M, Rataj-Baniowska M, Zinter N, Baldassarro VA, Fraulob V, Charles AL, Alvarez R, Muramatsu SI, de Lera AR, Geny B, Dollé P, Niewiadomska-Cimicka A, Krezel W
Prog Neurobiol. 2022 Feb 10;:102246
Retinoid X Receptor: Cellular and Biochemical Roles of Nuclear Receptor with a Focus on Neuropathological Involvement.
Sharma S, Shen T, Chitranshi N, Gupta V, Basavarajappa D, Mirzaei M, You Y, Krezel W, Graham SL, Gupta V
Mol Neurobiol. 2022 Jan 11;:
Counterion-insulated near-infrared dyes in biodegradable polymer nanoparticles for imaging.
Sobska J, Andreiuk B, Aparin IO, Reisch A, Krezel W, Klymchenko AS
Nanoscale Adv. 2021 Dec 21;4(1):39-48
Intronic elements associated with insomnia and restless legs syndrome exhibit cell type-specific epigenetic features contributing to MEIS1 regulation.
Lam DD, Nikolic AA, Zhao C, Mirza-Schreiber N, Krężel W, Oexle K, Winkelmann J
Hum Mol Genet. 2021 Dec 9;:
Vitamin A5/X controls stress-adaptation and prevents depressive-like behaviors in a mouse model of chronic stress.
Krzyżosiak A, Podleśny-Drabiniok A, Vaz B, Alvarez R, Rühl R, de Lera AR, Krężel W
Neurobiol Stress. 2021 Nov;15:100375
Plasma induced acceleration and selectivity in strain-promoted azide-alkyne cycloadditions.
Warther D, Dursun E, Recher M, Ursuegui S, Mosser M, Sobska J, Krezel W, Chaubet G, Wagner A
Org Biomol Chem. 2021 May 24;:
Investigation of dopaminergic signalling in Meis homeobox 1 (Meis1) deficient mice as an animal model of restless legs syndrome.
Cathiard L, Fraulob V, Lam DD, Torres M, Winkelmann J, Krężel W
J Sleep Res. 2021 May 18;:e13311
Gold Nanoclusters Display Low Immunogenic Effect in Microglia Cells.
Sobska J, Waszkielewicz M, Podleśny-Drabiniok A, Olesiak-Banska J, Krężel W, Matczyszyn K
Nanomaterials (Basel). 2021 Apr 21;11(5):
Vitamin A5/X, a New Food to Lipid Hormone Concept for a Nutritional Ligand to Control RXR-Mediated Signaling.
Krężel W, Rivas A, Szklenar M, Ciancia M, Alvarez R, de Lera AR, Rühl R
Nutrients. 2021 Mar 12;13(3):
Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.
Klyuyeva AV, Belyaeva OV, Goggans KR, Krezel W, Popov KM, Kedishvili NY
J Biol Chem. 2021 Jan 21;:100323
Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight.
Lee SA, Yang KJZ, Brun PJ, Silvaroli JA, Yuen JJ, Shmarakov I, Jiang H, Feranil JB, Li X, Lackey AI, Krężel W, Leibel RL, Libien J, Storch J, Golczak M, Blaner WS
Sci Adv. 2020 Mar;6(11):eaay8937
Alternative retinoid X receptor (RXR) ligands.
Krężel W, Rühl R, de Lera AR
Mol. Cell. Endocrinol.. 2019 07 1;491:110436
The role of nuclear receptors in the differentiation of oligodendrocyte precursor cells derived from fetal and adult neural stem cells.
Baldassarro VA, Krężel W, Fernández M, Schuhbaur B, Giardino L, Calzà L
Stem Cell Res. 2019 05;37:101443
9-Cis-13,14-dihydroretinoic acid, a new endogenous mammalian ligand of retinoid X receptor and the active ligand of a potential new vitamin A category: vitamin A5.
Rühl R, Krezel W, de Lera AR
Nutr. Rev.. 2018 12 1;76(12):929-941
Neuron-Astroglia Cell Fate Decision in the Adult Mouse Hippocampal Neurogenic Niche Is Cell-Intrinsically Controlled by COUP-TFI In Vivo.
Bonzano S, Crisci I, Podlesny-Drabiniok A, Rolando C, Krezel W, Studer M, De Marchis S
Cell Rep. 2018 07 10;24(2):329-341
Distinct retinoic acid receptor (RAR) isotypes control differentiation of embryonal carcinoma cells to dopaminergic or striatopallidal medium spiny neurons.
Podleśny-Drabiniok A, Sobska J, de Lera AR, Gołembiowska K, Kamińska K, Dollé P, Cebrat M, Krężel W
Sci Rep. 2017 Oct 20;7(1):13671
Development and evaluation of β-galactosidase-sensitive antibody-drug conjugates.
Kolodych S, Michel C, Delacroix S, Koniev O, Ehkirch A, Eberova J, Cianférani S, Renoux B, Krezel W, Poinot P, Muller CD, Papot S, Wagner A
Eur J Med Chem. 2017 Aug;:
An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin.
Ursuegui S, Recher M, Krężel W, Wagner A
Nat Commun. 2017 May;8:15242
Genome-wide Analysis of RARβ Transcriptional Targets in Mouse Striatum Links Retinoic Acid Signaling with Huntington's Disease and Other Neurodegenerative Disorders.
Niewiadomska-Cimicka A, Krzyżosiak A, Ye T, Podleśny-Drabiniok A, Dembélé D, Dollé P, Krężel W
Mol. Neurobiol.. 2016 Jul;:
Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons.
Tabet R, Moutin E, Becker JA, Heintz D, Fouillen L, Flatter E, Krężel W, Alunni V, Koebel P, Dembélé D, Tassone F, Bardoni B, Mandel JL, Vitale N, Muller D, Le Merrer J, Moine H
Proc. Natl. Acad. Sci. U.S.A.. 2016 06;113(26):E3619-28
An Endogenous Mammalian Retinoid X Receptor Ligand, At Last!
de Lera ÁR, Krezel W, Rühl R
ChemMedChem. 2016 05 19;11(10):1027-37
Retinoic Acid Receptor β Controls Development of Striatonigral Projection Neurons through FGF-Dependent and Meis1-Dependent Mechanisms.
Rataj-Baniowska M, Niewiadomska-Cimicka A, Paschaki M, Szyszka-Niagolov M, Carramolino L, Torres M, Dollé P, Krężel W
J. Neurosci.. 2015 Oct;35(43):14467-75
9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice.
Ruhl R, Krzyzosiak A, Niewiadomska-Cimicka A, Rochel N, Szeles L, Vaz B, Wietrzych-Schindler M, Alvarez S, Szklenar M, Nagy L, de Lera AR, Krezel W
PLoS Genet. 2015 Jun 1;11(6):e1005213
Increased Viral Dissemination in the Brain and Lethality in MCMV-Infected, Dicer-Deficient Neonates.
Ostermann E, Macquin C, Krezel W, Bahram S, Georgel P
Viruses. 2015 May 6;7(5):2308-20
Retinoic acid deficiency impairs the vestibular function.
Romand R, Krezel W, Beraneck M, Cammas L, Fraulob V, Messaddeq N, Kessler P, Hashino E, Dolle P
J Neurosci. 2013 Mar 27;33(13):5856-66
The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord.
Meziane H, Fraulob V, Riet F, Krezel W, Selloum M, Geffarth M, Acampora D, Herault Y, Simeone A, Brand M, Dolle P, Rhinn M
PeerJ. 2013 Aug 29;1:e142
Retinoid x receptor gamma is implicated in docosahexaenoic acid modulation of despair behaviors and working memory in mice.
Wietrzych-Schindler M, Szyszka-Niagolov M, Ohta K, Endo Y, Perez E, de Lera AR, Chambon P, Krezel W
Biol Psychiatry. 2011 Apr 15;69(8):788-94
Retinoid X receptor gamma signaling accelerates CNS remyelination.
Huang JK, Jarjour AA, Oumesmar BN, Kerninon C, Williams A, Krezel W, Kagechika H, Bauer J, Zhao C, Evercooren AB, Chambon P, Ffrench-Constant C, Franklin RJ
Nat Neurosci. 2011 Jan;14(1):45-53
Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study.
Mandillo S, Tucci V, Holter SM, Meziane H, Banchaabouchi MA, Kallnik M, Lad HV, Nolan PM, Ouagazzal AM, Coghill EL, Gale K, Golini E, Jacquot S, Krezel W, Parker A, Riet F, Schneider I, Marazziti D, Auwerx J, Brown SD, Chambon P, Rosenthal N, Tocchini-Valentini G, Wurst W
Physiol Genomics. 2008 Aug 15;34(3):243-55
Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.
Calleja C, Messaddeq N, Chapellier B, Yang H, Krezel W, Li M, Metzger D, Mascrez B, Ohta K, Kagechika H, Endo Y, Mark M, Ghyselinck NB, Chambon P
Genes Dev. 2006 Jun 1;20(11):1525-38.
Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis.
Sharma V, Hays WR, Wood WM, Pugazhenthi U, St Germain DL, Bianco AC, Krezel W, Chambon P, Haugen BR
Endocrinology. 2006 Mar;147(3):1438-51
Working memory deficits in retinoid X receptor gamma-deficient mice.
Wietrzych M, Meziane H, Sutter A, Ghyselinck N, Chapman PF, Chambon P, Krezel W
Learn Mem. 2005 May-Jun;12(3):318-26
Retinoid X receptor gamma-deficient mice have increased skeletal muscle lipoprotein lipase activity and less weight gain when fed a high-fat diet.
Haugen BR, Jensen DR, Sharma V, Pulawa LK, Hays WR, Krezel W, Chambon P, Eckel RH
Endocrinology. 2004 Aug;145(8):3679-85
Aberrant growth plate development in VDR/RXR gamma double null mutant mice.
Yagishita N, Yamamoto Y, Yoshizawa T, Sekine K, Uematsu Y, Murayama H, Nagai Y, Krezel W, Chambon P, Matsumoto T, Kato S
Endocrinology. 2001 Dec;142(12):5332-41
Increased anxiety and synaptic plasticity in estrogen receptor beta -deficient mice.
Krezel W, Dupont S, Krust A, Chambon P, Chapman PF
Proc. Natl. Acad. Sci. U.S.A.. 2001 Oct;98(21):12278-82
Differential contributions of AF-1 and AF-2 activities to the developmental functions of RXR alpha.
Mascrez B, Mark M, Krezel W, Dupé V, LeMeur M, Ghyselinck NB, Chambon P
Development. 2001 Jun;128(11):2049-62
Thyroid hormone resistance and increased metabolic rate in the RXR-gamma-deficient mouse.
Brown NS, Smart A, Sharma V, Brinkmeier ML, Greenlee L, Camper SA, Jensen DR, Eckel RH, Krezel W, Chambon P, Haugen BR
J. Clin. Invest.. 2000 Jul;106(1):73-9
Compensatory mechanism of motor defect in SOD1 transgenic mice by overactivation of striatal cholinergic neurons.
Azzouz M, Krezel W, Dollé P, Vodouhe C, Warter JM, Poindron P, Borg J
Neuroreport. 1999 Apr 6;10(5):1013-8
Differential expression of retinoid receptors in the adult mouse central nervous system.
Krezel W, Kastner P, Chambon P
Neuroscience. 1999 ;89(4):1291-300
Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis.
Barros AC, Erway LC, Krezel W, Curran T, Kastner P, Chambon P, Forrest D
Neuroreport. 1998 Sep;9(13):2933-7
Impaired locomotion and dopamine signaling in retinoid receptor mutant mice.
Krezel W, Ghyselinck N, Samad TA, Dupé V, Kastner P, Borrelli E, Chambon P
Science. 1998 Feb;279(5352):863-7
Mesectoderm is a major target of retinoic acid action.
Mark M, Ghyselinck NB, Kastner P, Dupé V, Wendling O, Krezel W, Mascrez B, Chambon P
Eur. J. Oral Sci.. 1998 Jan;106 Suppl 1:24-31
Regulation of dopaminergic pathways by retinoids: activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid X receptor family.
Samad TA, Krezel W, Chambon P, Borrelli E
Proc. Natl. Acad. Sci. U.S.A.. 1997 Dec;94(26):14349-54
Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development.
Kastner P, Mark M, Ghyselinck N, Krezel W, Dupé V, Grondona JM, Chambon P
Development. 1997 Jan;124(2):313-26
[Genetic control of the development by retinoic acid].
Mark M, Kastner P, Ghyselinck NB, Krezel W, Dupé V, Chambon P
C. R. Seances Soc. Biol. Fil.. 1997 ;191(1):77-90
RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.
Krezel W, Dupé V, Mark M, Dierich A, Kastner P, Chambon P
Proc. Natl. Acad. Sci. U.S.A.. 1996 Aug;93(17):9010-4
Abnormal spermatogenesis in RXR beta mutant mice.
Kastner P, Mark M, Leid M, Gansmuller A, Chin W, Grondona JM, Décimo D, Krezel W, Dierich A, Chambon P
Genes Dev.. 1996 Jan;10(1):80-92
