Fiche personne
Coordonnées
UMR CNRS/URCA 7369 MEDyC
UFR Sciences Exactes et Naturelles
Campus du Moulin de la Housse
BP 1039
51687 REIMS Cedex 2
Territoire
Alsace
Statut
Enseignant-Chercheur
Affiliation
Université de Reims Champagne-Ardenne (URCA)
UMR CNRS 7369 MEDyC - Matrice extracellulaire et dynamique cellulaire (MEDyC)
Équipes/plateformes
UMR 7369 MEDyC - Equipe "Vieillissement matriciel et remodelage vasculaire"
Publications
Restoring lysosomal proteostasis reverses steatohepatitis and fibrosis in experimental MASH.
Mastrippolito D, Gur L, Lasalo M, Kaakour LE, Verdot C, Coste F, Blaise S, Muller S
Pharmacol Res. 2026 09 1;232:108427
Novel Bioactive Multifunctional Polyphenols: A Chemo-Enzymatic Approach.
Flourat AL, Thiébault E, Martinez A, Brunissen F, Dosso A, Oszust F, Blaise S, Romier B, Allais F
Chemistry. 2025 12 26;:e03176
Minoxidil and nebivolol restore aortic elastic fiber homeostasis in diabetic mice via potassium channel activation.
Henry A, Vanalderwiert L, Oszust F, Wahart A, Carvajal Berrio DA, Brauchle EM, Schenke-Layland K, Brinckmann J, Steenbock H, Debelle L, Six I, Faury G, Jaisson S, Gillery P, Durlarch V, Sartelet H, Maurice P, Bennasroune A, Martiny L, Duca L, Romier B, Blaise S
Front Physiol. 2025 09 18;16:1648727
Exploring aortic stiffness in aging mice: a comprehensive methodological overview.
Vanalderwiert L, Henry A, de Souza E Silva JM, Carvajal-Berrio D, Debelle L, Wahart A, Marzi J, Schenke-Layland K, Faury G, Six I, Schmelzer CEH, Brinckmann J, Steenbock H, Almagro S, Delacoux F, Jaisson S, Gillery P, Maurice P, Sartelet H, Bennasroune A, Duca L, Romier B, Blaise S
Aging (Albany NY). 2024 12 2;null:
METABOLIC SYNDROME-ASSOCIATED MURINE AORTIC WALL STIFFENING IS ASSOCIATED WITH PREMATURE ELASTIC FIBERS AGING.
Vanalderwiert L, Henry A, Wahart A, Carvajal Berrio DA, Brauchle EM, El Kaakour L, Schenke-Layland K, Brinckmann J, Steenbock H, Debelle L, Six I, Faury G, Jaisson S, Gillery P, Durlach V, Sartelet H, Maurice P, Bennasroune A, Martiny L, Duca L, Romier B, Blaise S
Am J Physiol Cell Physiol. 2024 07 1;:
Inhibition of neuraminidase-1 sialidase activity by interfering peptides impairs insulin receptor activity in vitro and glucose homeostasis in vivo.
Toussaint K, Appert-Collin A, Vanalderwiert L, Bour C, Terryn C, Spenlé C, Van Der Heyden M, Roumieux M, Maurice P, Romier-Crouzet B, Sartelet H, Duca L, Blaise S, Bennasroune A
J Biol Chem. 2024 04 23;:107316
Sialic acids cleavage induced by elastin-derived peptides impairs the interaction between insulin and its receptor in adipocytes 3T3-L1.
Guillot A, Toussaint K, Ebersold L, ElBtaouri H, Thiebault E, Issad T, Peiretti F, Maurice P, Sartelet H, Bennasroune A, Martiny L, Dauchez M, Duca L, Durlach V, Romier B, Baud S, Blaise S
J Physiol Biochem. 2024 02 23;:
Neuraminidase-1: A Sialidase Involved in the Development of Cancers and Metabolic Diseases.
Toussaint K, Appert-Collin A, Morjani H, Albrecht C, Sartelet H, Romier-Crouzet B, Maurice P, Duca L, Blaise S, Bennasroune A
Cancers (Basel). 2022 10 5;14(19):
Early Alterations of Intra-Mural Elastic Lamellae Revealed by Synchrotron X-ray Micro-CT Exploration of Diabetic Aortas.
Ben Zemzem A, Liang X, Vanalderwiert L, Bour C, Romier-Crouzet B, Blaise S, Sherratt MJ, Weitkamp T, Dauchez M, Baud S, Passat N, Debelle L, Almagro S
Int J Mol Sci. 2022 Mar 17;23(6):
The Elastin Receptor Complex: An Emerging Therapeutic Target Against Age-Related Vascular Diseases.
Tembely D, Henry A, Vanalderwiert L, Toussaint K, Bennasroune A, Blaise S, Sartelet H, Jaisson S, Galés C, Martiny L, Duca L, Romier-Crouzet B, Maurice P
Front Endocrinol (Lausanne). 2022 ;13:815356
Characterization of novel interactions with membrane NEU1 highlights new regulatory functions for the Elastin Receptor Complex in monocyte interaction with endothelial cells.
Bocquet O, Tembely D, Rioult D, Terryn C, Romier B, Bennasroune A, Blaise S, Sartelet H, Martiny L, Duca L, Maurice P
Cell Biosci. 2021 Dec 13;11(1):206
Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall.
Romier B, Dray C, Vanalderwiert L, Wahart A, Hocine T, Dortignac A, Garbar C, Garbar C, Boulagnon C, Bouland N, Maurice P, Bennasroune A, Sartelet H, Martiny L, Duca L, Valet P, Blaise S
Sci Rep. 2021 Nov 15;11(1):22278
X-ray microtomography reveals a lattice-like network within aortic elastic lamellae.
Ben Zemzem A, Genevaux A, Wahart A, Bodey AJ, Blaise S, Romier-Crouzet B, Jonquet J, Bour C, Cogranne R, Beauseroy P, Dauchez M, Sherratt MJ, Debelle L, Almagro S
FASEB J. 2021 Oct;35(10):e21844
Fetal Programming by Methyl Donor Deficiency Produces Pathological Remodeling of the Ascending Aorta.
Balint B, Hergalan S, Camadro JM, Blaise S, Vanalderwiert L, Lignières L, Guéant-Rodriguez RM, Guéant JL
Arterioscler Thromb Vasc Biol. 2021 Apr 8;:ATVBAHA120315587
Adverse effects of oseltamivir phosphate therapy on the liver of LDLR-/- mice without any benefit on atherosclerosis and thrombosis.
Bocquet O, Wahart A, Sarazin T, Vincent E, Schneider C, Fougerat A, Gayral S, Henry A, Blaise S, Romier-Crouzet B, Boulagnon C, Jaisson S, Gillery PP, Bennasroune A, Sartelet H, Laffargue M, Martiny PL, Duca PL, Maurice P
J Cardiovasc Pharmacol. 2021 Feb 25;:
Revealing the elasticity of an individual aortic fiber during ageing at nanoscale by atomic force microscopy.
Berquand A, Wahart A, Henry A, Gorisse L, Maurice P, Blaise S, Romier-Crouzet B, Pietrement C, Bennasroune A, Sartelet H, Jaisson S, Gillery P, Martiny L, Touré F, Duca L, Molinari M
Nanoscale. 2021 Jan 5;:
Lactosylceramide induced by elastin-derived peptides decreases adipocyte differentiation.
Hocine T, Blaise S, Hachet C, Guillot A, Sartelet H, Maurice P, Bennasroune A, Martiny L, Duca L, Romier-Crouzet B, El Btaouri H
J. Physiol. Biochem.. 2020 Jun 26;:
Transmembrane Peptides as a New Strategy to Inhibit Neuraminidase-1 Activation.
Albrecht C, Kuznetsov AS, Appert-Collin A, Dhaideh Z, Callewaert M, Bershatsky YV, Urban AS, Bocharov EV, Bagnard D, Baud S, Blaise S, Romier-Crouzet B, Efremov RG, Dauchez M, Duca L, Gueroult M, Maurice P, Bennasroune A
Front Cell Dev Biol. 2020 ;8:611121
Transmembrane Peptides as Inhibitors of Protein-Protein Interactions: An Efficient Strategy to Target Cancer Cells?
Albrecht C, Appert-Collin A, Bagnard D, Blaise S, Romier-Crouzet B, Efremov RG, Sartelet H, Duca L, Maurice P, Bennasroune A
Front Oncol. 2020 ;10:519
Umbrella Visualization: a method of analysis dedicated to glycan flexibility with UnityMol.
Besançon C, Guillot A, Blaise S, Dauchez M, Belloy N, Prévoteau-Jonquet J, Baud S
Methods. 2019 Jul 11;:
Elastic fibers and elastin receptor complex: Neuraminidase-1 takes the center stage.
Bennasroune A, Romier-Crouzet B, Blaise S, Laffargue M, Efremov RG, Martiny L, Maurice P, Duca L
Matrix Biol.. 2019 Jun 18;:
Role of Elastin Peptides and Elastin Receptor Complex in metabolic and cardiovascular diseases.
Wahart A, Hocine T, Albrecht C, Henry A, Sarazin T, Martiny L, Btaouri HE, Maurice P, Bennasroune A, Romier-Crouzet B, Blaise S, Duca L
FEBS J.. 2019 Apr 4;:
Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex.
Kawecki C, Bocquet O, Schmelzer CEH, Heinz A, Ihling C, Wahart A, Romier B, Bennasroune A, Blaise S, Terryn C, Linton KJ, Martiny L, Duca L, Maurice P
Cell. Mol. Life Sci.. 2018 Nov 29;:
Production of Elastin-Derived Peptides Contribute to the Development of Non-Alcoholic Steatohepatitis.
Romier B, Ivaldi C, Sartelet H, Heinz A, Schmelzer CEH, Garnotel R, Guillot A, Jonquet J, Bertin E, Guéant JL, Alberto JM, Bronowicki JP, Amoyel J, Hocine T, Duca L, Maurice P, Bennasroune A, Martiny L, Debelle L, Durlach V, Blaise S
Diabetes. 2018 May 25;:
New Insights into Molecular Organization of Human Neuraminidase-1: Transmembrane Topology and Dimerization Ability.
Maurice P, Baud S, Bocharova OV, Bocharov EV, Kuznetsov AS, Kawecki C, Bocquet O, Romier B, Gorisse L, Ghirardi M, Duca L, Blaise S, Martiny L, Dauchez M, Efremov RG, Debelle L
Sci Rep. 2016 Dec;6:38363
Impact of sialic acids on the molecular dynamic of bi-antennary and tri-antennary glycans.
Guillot A, Dauchez M, Belloy N, Jonquet J, Duca L, Romier B, Maurice P, Debelle L, Martiny L, Durlach V, Baud S, Blaise S
Sci Rep. 2016 Oct;6:35666
Matrix ageing and vascular impacts: focus on elastin fragmentation.
Duca L, Blaise S, Romier B, Laffargue M, Gayral S, El Btaouri H, Kawecki C, Guillot A, Martiny L, Debelle L, Maurice P
Cardiovasc. Res.. 2016 06;110(3):298-308
Matrix metalloproteinase 11 protects from diabesity and promotes metabolic switch.
Dali-Youcef N, Hnia K, Blaise S, Messaddeq N, Blanc S, Postic C, Valet P, Tomasetto C, Rio MC
Sci Rep. 2016 Apr;6:25140
The Elastin Receptor Complex: A Unique Matricellular Receptor with High Anti-tumoral Potential.
Scandolera A, Odoul L, Salesse S, Guillot A, Blaise S, Kawecki C, Maurice P, El Btaouri H, Romier-Crouzet B, Martiny L, Debelle L, Duca L
Front Pharmacol. 2016 ;7:32
Uncoupling of Elastin Complex Receptor during In Vitro Aging Is Related to Modifications in Its Intrinsic Sialidase Activity and the Subsequent Lactosylceramide Production.
Scandolera A, Rabenoelina F, Chaintreuil C, Rusciani A, Maurice P, Blaise S, Romier-Crouzet B, El Btaouri H, Martiny L, Debelle L, Duca L
PLoS One. 2015 Jun 18;10(6):e0129994
Elastin-derived peptides are new regulators of thrombosis.
Kawecki C, Hezard N, Bocquet O, Poitevin G, Rabenoelina F, Kauskot A, Duca L, Blaise S, Romier B, Martiny L, Nguyen P, Debelle L, Maurice P
Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2570-8
Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kgamma pathway.
Gayral S, Garnotel R, Castaing-Berthou A, Blaise S, Fougerat A, Berge E, Montheil A, Malet N, Wymann MP, Maurice P, Debelle L, Martiny L, Martinez LO, Pshezhetsky AV, Duca L, Laffargue M
Cardiovasc Res. 2014 Apr 1;102(1):118-27
Elastin-derived peptides are new regulators of insulin resistance development in mice.
Blaise S, Romier B, Kawecki C, Ghirardi M, Rabenoelina F, Baud S, Duca L, Maurice P, Heinz A, Schmelzer CE, Tarpin M, Martiny L, Garbar C, Dauchez M, Debelle L, Durlach V
Diabetes. 2013 Nov;62(11):3807-16
Interaction between the elastin peptide VGVAPG and human elastin binding protein.
Blanchevoye C, Floquet N, Scandolera A, Baud S, Maurice P, Bocquet O, Blaise S, Ghoneim C, Cantarelli B, Delacoux F, Dauchez M, Efremov RG, Martiny L, Duca L, Debelle L
J Biol Chem. 2013 Jan 11;288(2):1317-28
Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver.
Pooya S, Blaise S, Moreno Garcia M, Giudicelli J, Alberto JM, Guéant-Rodriguez RM, Jeannesson E, Gueguen N, Bressenot A, Nicolas B, Malthiery Y, Daval JL, Peyrin-Biroulet L, Bronowicki JP, Guéant JL
J. Hepatol.. 2012 Aug;57(2):344-51
In vivo evidence that TRAF4 is required for central nervous system myelin homeostasis.
Blaise S, Kneib M, Rousseau A, Gambino F, Chenard MP, Messadeq N, Muckenstrum M, Alpy F, Tomasetto C, Humeau Y, Rio MC
PLoS One. 2012;7(2):e30917
Matrix metalloproteinase 11/stromelysin-3 exerts both activator and repressor functions during the hematogenous metastatic process in mice.
Brasse D, Mathelin C, Leroux K, Chenard MP, Blaise S, Stoll I, Tomasetto C, Rio MC
Int J Cancer. 2010 Sep 1;127(6):1347-55.
Elastin peptides signaling relies on neuraminidase-1-dependent lactosylceramide generation.
Rusciani A, Duca L, Sartelet H, Chatron-Colliet A, Bobichon H, Ploton D, Le Naour R, Blaise S, Martiny L, Debelle L
PLoS One. 2010 Nov 16;5(11):e14010.
Methyl donor deficiency affects fetal programming of gastric ghrelin cell organization and function in the rat.
Bossenmeyer-Pourie C, Blaise S, Pourie G, Tomasetto C, Audonnet S, Ortiou S, Koziel V, Rio MC, Daval JL, Gueant JL, Beck B
Am J Pathol. 2010 Jan;176(1):270-7
Matrix metalloproteinase-11/stromelysin-3 exhibits collagenolytic function against collagen VI under normal and malignant conditions.
Motrescu ER, Blaise S, Etique N, Messaddeq N, Chenard MP, Stoll I, Tomasetto C, Rio MC
Oncogene. 2008 Oct 23;27(49):6347-55