Dupouy B, Donzel M, Roignant M, Charital S, Keumoe R, Yamaryo-Botté Y, Feckler A, Bundschuh M, Bordat Y, Rottmann M, Mäser P, Botté CY, Blandin SA, Besteiro S, Davioud-Charvet E

ACS Infect Dis. 2024 09 26;:

Proteomic Profiling of Antimalarial Plasmodione Using 3-Benz(o)ylmenadione Affinity-Based Probes.

Iacobucci I, Monaco V, Hovasse A, Dupouy B, Keumoe R, Cichocki B, Elhabiri M, Meunier B, Strub JM, Monti M, Cianférani S, Blandin SA, Schaeffer-Reiss C, Davioud-Charvet E

Chembiochem. 2024 04 19;:e202400187

Synthesis and Anti-Chagas Activity Profile of a Redox-Active Lead 3-Benzylmenadione Revealed by High-Content Imaging.

Trometer N, Pecourneau J, Feng L, Navarro-Huerta JA, Lazarin-Bidóia D, de Oliveira Silva Lautenschlager S, Maes L, Fortes Francisco A, Kelly JM, Meunier B, Cal M, Mäser P, Kaiser M, Davioud-Charvet E

ACS Infect Dis. 2024 04 12;:

Chemoselective Synthesis and Anti-Kinetoplastidal Properties of 2,6-Diaryl-4-tetrahydro-thiopyran-4-one -Oxides: Their Interplay in a Cascade of Redox Reactions from Diarylideneacetones.

Gendron T, Lanfranchi DA, Wenzel NI, Kessedjian H, Jannack B, Maes L, Cojean S, Müller TJJ, Loiseau PM, Davioud-Charvet E

Molecules. 2024 04 4;29(7):

Synthesis and Photochemical Properties of Fluorescent Metabolites Generated from Fluorinated Benzoylmenadiones in Living Cells.

Trometer N, Cichocki B, Chevalier Q, Pécourneau J, Strub JM, Hemmerlin A, Specht A, Davioud-Charvet E, Elhabiri M

J Org Chem. 2023 06 2;:

Evaluation of ferrocenyl-containing γ-hydroxy-γ-lactam-derived tetramates as potential antiplasmodials.

Chopin N, Bosson J, Iikawa S, Picot S, Bienvenu AL, Lavoignat A, Bonnot G, Riou M, Beaugé C, Guillory V, Biot C, Pilet G, Chessé M, Davioud-Charvet E, Elhabiri M, Bouillon JP, Médebielle M

Eur J Med Chem. 2022 09 12;243:114735

The parasitophorous vacuole nutrient channel is critical for drug access in malaria parasites and modulates the artemisinin resistance fitness cost.

Mesén-Ramírez P, Bergmann B, Elhabiri M, Zhu L, von Thien H, Castro-Peña C, Gilberger TW, Davioud-Charvet E, Bozdech Z, Bachmann A, Spielmann T

Cell Host Microbe. 2021 Nov 30;:

Bioinspired Photoredox Benzylation of Quinones.

Donzel M, Elhabiri M, Davioud-Charvet E

J Org Chem. 2021 Jul 15;:

A Class of Valuable (Pro-)Activity-Based Protein Profiling Probes: Application to the Redox-Active Antiplasmodial Agent, Plasmodione.

Cichocki BA, Khobragade V, Donzel M, Cotos L, Blandin S, Schaeffer-Reiss C, Cianférani S, Strub JM, Elhabiri M, Davioud-Charvet E

JACS Au. 2021 May 24;1(5):669-689

A role for the succinate dehydrogenase in the mode of action of the redox-active antimalarial drug, plasmodione.

Mounkoro P, Michel T, Golinelli-Cohen MP, Blandin S, Davioud-Charvet E, Meunier B

Free Radic Biol Med. 2020 Nov 21;:

Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on Glutathione Reductase.

Marozienė A, Lesanavičius M, Davioud-Charvet E, Aliverti A, Grellier P, Šarlauskas J, Čėnas N

Molecules. 2019 Dec 10;24(24):

A Mild and Versatile Friedel-Crafts Methodology for the Diversity-Oriented Synthesis of Redox-Active 3-Benzoylmenadiones with Tuneable Redox Potentials.

Cotos L, Donzel M, Elhabiri M, Davioud-Charvet E

Chemistry. 2019 Nov 20;:

Selenium status in elderly people: Longevity and age-related diseases.

Robberecht H, De Bruyne T, Davioud-Charvet E, Mackrill J, Hermans N

Curr. Pharm. Des.. 2019 Jul 1;:

Investigating the mode of action of the redox-active antimalarial drug plasmodione using the yeast model.

Mounkoro P, Michel T, Blandin S, Golinelli-Cohen MP, Davioud-Charvet E, Meunier B

Free Radic. Biol. Med.. 2019 Jun 22;:

Physicochemical Properties Govern the Activity of Potent Antiviral Flavones.

Martin-Benlloch X, Haid S, Novodomska A, Rominger F, Pietschmann T, Davioud-Charvet E, Elhabiri M

ACS Omega. 2019 Mar 31;4(3):4871-4887

AntiMalarial Mode of Action (AMMA) Database: Data Selection, Verification and Chemical Space Analysis.

Sidorov P, Davioud-Charvet E, Marcou G, Horvath D, Varnek A

Mol Inform. 2018 May 11;:

Synthesis of plasmodione metabolites and C-enriched plasmodione as chemical tools for drug metabolism investigation.

Feng L, Lanfranchi DA, Cotos L, Cesar-Rodo E, Ehrhardt K, Goetz AA, Zimmermann H, Fenaille F, Blandin SA, Davioud-Charvet E

Org. Biomol. Chem.. 2018 Apr 18;16(15):2647-2665

QSAR modeling and chemical space analysis of antimalarial compounds.

Sidorov P, Viira B, Davioud-Charvet E, Maran U, Marcou G, Horvath D, Varnek A

J. Comput. Aided Mol. Des.. 2017 May;31(5):441-451

A high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase-based mature gametocyte assay.

Siciliano G, Santha Kumar TR, Bona R, Camarda G, Calabretta MM, Cevenini L, Davioud-Charvet E, Becker K, Cara A, Fidock DA, Alano P

Mol. Microbiol.. 2017 Apr;104(2):306-318

Arylmethylamino steroids as antiparasitic agents.

Krieg R, Jortzik E, Goetz AA, Blandin S, Wittlin S, Elhabiri M, Rahbari M, Nuryyeva S, Voigt K, Dahse HM, Brakhage A, Beckmann S, Quack T, Grevelding CG, Pinkerton AB, Schönecker B, Burrows J, Davioud-Charvet E, Rahlfs S, Becker K

Nat Commun. 2017 Feb 17;8:14478

A Redox-Active Fluorescent pH Indicator for Detecting Plasmodium falciparum Strains with Reduced Responsiveness to Quinoline Antimalarial Drugs.

Jida M, Sanchez CP, Urgin K, Ehrhardt K, Mounien S, Geyer A, Elhabiri M, Lanzer M, Davioud-Charvet E

ACS Infect Dis. 2017 Feb 10;3(2):119-131

Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties.

Urgin K, Jida M, Ehrhardt K, Müller T, Lanzer M, Maes L, Elhabiri M, Davioud-Charvet E

Molecules. 2017 Jan 19;22(1):

The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites.

Ehrhardt K, Deregnaucourt C, Goetz AA, Tzanova T, Gallo V, Arese P, Pradines B, Adjalley SH, Bagrel D, Blandin S, Lanzer M, Davioud-Charvet E

Antimicrob. Agents Chemother.. 2016 09;60(9):5146-58

In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids.

Viira B, Gendron T, Lanfranchi DA, Cojean S, Horvath D, Marcou G, Varnek A, Maes L, Maran U, Loiseau PM, Davioud-Charvet E

Molecules. 2016 Jun 29;21(7):

Redox Polypharmacology as an Emerging Strategy to Combat Malarial Parasites.

Sidorov P, Desta I, Chessé M, Horvath D, Marcou G, Varnek A, Davioud-Charvet E, Elhabiri M

ChemMedChem. 2016 06 20;11(12):1339-51

Synthesis and evaluation of 1,4-naphthoquinone ether derivatives as SmTGR inhibitors and new anti-schistosomal drugs.

Johann L, Belorgey D, Huang HH, Day L, Chessé M, Becker K, Williams DL, Davioud-Charvet E

FEBS J.. 2015 Aug;282(16):3199-217

Antimalarial NADPH-Consuming Redox-Cyclers As Superior Glucose-6-Phosphate Dehydrogenase Deficiency Copycats.

Bielitza M, Belorgey D, Ehrhardt K, Johann L, Lanfranchi DA, Gallo V, Schwarzer E, Mohring F, Jortzik E, Williams DL, Becker K, Arese P, Elhabiri M, Davioud-Charvet E

Antioxid. Redox Signal.. 2015 May 20;22(15):1337-51

Electrochemical properties of substituted 2-methyl-1,4-naphthoquinones: redox behavior predictions.

Elhabiri M, Sidorov P, Cesar-Rodo E, Marcou G, Lanfranchi DA, Davioud-Charvet E, Horvath D, Varnek A

Chemistry. 2015 Feb 16;21(8):3415-24

Antiglioma activity of GoPI-sugar, a novel gold(I)-phosphole inhibitor: chemical synthesis, mechanistic studies, and effectiveness in vivo.

Jortzik E, Farhadi M, Ahmadi R, Tóth K, Lohr J, Helmke BM, Kehr S, Unterberg A, Ott I, Gust R, Deborde V, Davioud-Charvet E, Réau R, Becker K, Herold-Mende C

Biochim. Biophys. Acta. 2014 Aug;1844(8):1415-26