Dr KOLODYCH Sergii

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Coordonnées

Syndivia
650 Boulevard Gonthier d’Andernach
67400 ILLKIRCH

+33 3 68 85 43 01

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Alsace

Statut

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Équipes/plateformes

Syndivia

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Mots clés : Targeted cancer therapies, Antibody-Drug Conjugates

Publications

Stoichiometric Antibody-Polymer-Drug Conjugate for Effective Low-Dose Treatment of Breast Cancer.

Lehot V, Lidický O, Most J, Nothisen M, Erb S, Dovgan I, Osypenko A, Koniev O, Kolodych S, Kotrchová L, Chaubet G, Cianférani S, Etrych T, Wagner A

Biomacromolecules. 2025 10 13;:

Selective Protein (Post-)modifications through Dynamic Covalent Chemistry: Self-activated SAr Reactions.

Esteve F, Schmitt JL, Kolodych S, Koniev O, Lehn JM

J Am Chem Soc. 2025 01 2;:

Antibody-Vincristine Conjugates as Potent Anticancer Therapeutic Agents.

Boos A, Most J, Cahuzac H, Moreira da Silva L, Daubeuf F, Erb S, Cianférani S, Hernandez-Alba O, Semenchenko C, Dovgan I, Kolodych S, Detappe A, Dantzer F, Wagner A, Zeniou M, Chaubet G

J Med Chem. 2024 12 16;:

INA03, a potent transferrin-competitive antibody-drug conjugate against CD71, for a safer acute leukemia treatment.

Bratti M, Stubbs E, Kolodych S, Souchet H, Kelly L, Merlin J, Marchal M, Castellano R, Josselin E, Pasquer H, Benajiba L, Puissant A, Koniev O, Collette Y, Belanger C, Hermine O, Monteiro RC, Launay P

Mol Cancer Ther. 2024 04 20;:

Reinvestigation of the Automated Synthesis of Stoichiometrically Conjugated Antibodies to Access High Molecular Weight Payloads and Multiplexed Conjugation via an In-Solution Trans-Tagging Process.

Lehot V, Lidický O, Most J, Erb S, Dovgan I, Osypenko A, Koniev O, Kolodych S, Kotrchová L, Chaubet G, Cianférani S, Etrych T, Wagner A

ACS Omega. 2023 10 31;8(43):40508-40516

Thermofluorimetric Analysis (TFA) using Probes with Flexible Spacers: Application to Direct Antibody Sensing and to Antibody-Oligonucleotide (AbO) Conjugate Valency Monitoring.

Kurian ASN, Gurukandure A, Dovgan I, Kolodych S, Easley CJ

Anal Chem. 2023 07 25;:

Non-specific interactions of antibody-oligonucleotide conjugates with living cells.

Lehot V, Kuhn I, Nothisen M, Erb S, Kolodych S, Cianférani S, Chaubet G, Wagner A

Sci Rep. 2021 Mar 15;11(1):5881

On the use of DNA as a linker in antibody-drug conjugates: synthesis, stability and in vitro potency.

Dovgan I, Ehkirch A, Lehot V, Kuhn I, Koniev O, Kolodych S, Hentz A, Ripoll M, Ursuegui S, Nothisen M, Cianférani S, Wagner A

Sci Rep. 2020 May 6;10(1):7691

Automated linkage of proteins and payloads producing monodisperse conjugates.

Dovgan I, Hentz A, Koniev O, Ehkirch A, Hessmann S, Ursuegui S, Delacroix S, Riomet M, Taran F, Cianférani S, Kolodych S, Wagner A

Chem Sci. 2020 Jan 2;11(5):1210-1215

Antibody-Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents.

Dovgan I, Koniev O, Kolodych S, Wagner A

Bioconjug. Chem.. 2019 Jul 24;:

Reduction-rebridging strategy for the preparation of ADPN-based antibody-drug conjugates.

Koniev O, Dovgan I, Renoux B, Ehkirch A, Eberova J, Cianférani S, Kolodych S, Papot S, Wagner A

Medchemcomm. 2018 May 1;9(5):827-830

Design and Synthesis of Iminosydnones for Fast Click and Release Reactions with Cycloalkynes.

Taran F, Riomet M, Decuypere E, Porte K, Bernard S, Plougastel L, Kolodych S, Audisio D

Chemistry. 2018 Apr 17;:

Bioorthogonal Click and Release Reaction of Iminosydnones with Cycloalkynes.

Bernard S, Audisio D, Riomet M, Bregant S, Sallustrau A, Plougastel L, Decuypere E, Gabillet S, Kumar RA, Elyian J, Trinh MN, Koniev O, Wagner A, Kolodych S, Taran F

Angew. Chem. Int. Ed. Engl.. 2017 Dec 4;56(49):15612-15616

Development and evaluation of β-galactosidase-sensitive antibody-drug conjugates.

Kolodych S, Michel C, Delacroix S, Koniev O, Ehkirch A, Eberova J, Cianférani S, Renoux B, Krezel W, Poinot P, Muller CD, Papot S, Wagner A

Eur J Med Chem. 2017 Aug;:

Targeting the tumour microenvironment with an enzyme-responsive drug delivery system for the efficient therapy of breast and pancreatic cancers.

Renoux B, Raes F, Legigan T, Péraudeau E, Eddhif B, Poinot P, Tranoy-Opalinski I, Alsarraf J, Koniev O, Kolodych S, Lerondel S, Le Pape A, Clarhaut J, Papot S

Chem Sci. 2017 May;8(5):3427-3433

Acyl Fluorides: Fast, Efficient, and Versatile Lysine-Based Protein Conjugation via Plug-and-Play Strategy.

Dovgan I, Ursuegui S, Erb S, Michel C, Kolodych S, Cianférani S, Wagner A

Bioconjug. Chem.. 2017 Apr;:

Ultrafast Click Chemistry with Fluorosydnones.

Liu H, Audisio D, Plougastel L, Decuypere E, Buisson DA, Koniev O, Kolodych S, Wagner A, Elhabiri M, Krzyczmonik A, Forsback S, Solin O, Gouverneur V, Taran F

Angew. Chem. Int. Ed. Engl.. 2016 Sep;55(39):12073-7