Dr NEGRONI Luc

Fiche personne

Coordonnées

IGBMC
Proteomic Platform
1 rue Laurent Fries
BP 10142
67404 ILLKIRCH

03 88 65 33 99

Territoire

Alsace

Statut

Ingénieur/Technicien

Affiliation

IGBMC - Institut de génétique et de biologie moléculaire et cellulaire (IGBMC)

Recherche

Mots clés : Spectrométrie de masse, Protéomique, PTM, bottom-up, protéine entière

Expertises :
- Plateforme:Protéomique

Publications

Heterozygous loss-of-function alleles associate the conserved 3'-5' exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5-fluorouracil.

Sain R, Le Page Y, Percevault F, Becker E, Negroni L, Fernandez A, Cantero M, Muñoz-Santos D, Montoliu L, Garnier C, Primig M

Mol Oncol. 2026 05 15;:

New proteomic signature in circulating extracellular vesicles from tumor-draining and peripheral veins of patients with lung adenocarcinoma.

Tricard J, Durand S, Rovini A, Gateau A, Negroni L, Chaunavel A, Chermat A, Jauberteau MO, Conti M, Akil H, Lalloué F

Cancer Cell Int. 2026 04 1;:

Quantitative analysis of DNA-GATA1 binding alterations linked to hematopoietic disorders.

Zambo B, Morlet B, Negroni L, Mózner O, Sarkadi B, Travé G, Gogl G

FEBS J. 2026 03 17;:

Interactome of the oncogenic ΔNp73α isoform in human papillomavirus 38 E6/E7-transformed keratinocytes.

Negroni L, Taverniti V, Tommasino M, Zanier K

Microbiol Resour Announc. 2025 03 26;:e0107124

RNA polymerase II transcription initiation in holo-TFIID-depleted mouse embryonic stem cells.

Hisler V, Bardot P, Detilleux D, Bernardini A, Stierle M, Sanchez EG, Richard C, Arab LH, Ehrhard C, Morlet B, Hadzhiev Y, Jung M, Le Gras S, Négroni L, Müller F, Tora L, Vincent SD

Cell Rep. 2024 09 30;43(10):114791

Uncovering the BIN1-SH3 interactome underpinning centronuclear myopathy.

Zambo B, Edelweiss E, Morlet B, Negroni L, Pajkos M, Dosztanyi Z, Ostergaard S, Trave G, Laporte J, Gogl G

Elife. 2024 07 12;13:

IRE1 endoribonuclease signaling promotes myeloid cell infiltration in glioblastoma.

Obacz J, Archambeau J, Lafont E, Nivet M, Martin S, Aubry M, Voutetakis K, Pineau R, Boniface R, Sicari D, Pelizzari-Raymundo D, Ghukasyan G, McGrath E, Vlachavas EI, Le Gallo M, Le Reste PJ, Barroso K, Fainsod-Levi T, Obiedat A, Granot Z, Tirosh B, Samal J, Pandit A, Négroni L, Soriano N, Monnier A, Mosser J, Chatziioannou A, Quillien V, Chevet E, Avril T

Neuro Oncol. 2023 12 28;:

Comparative analysis of PDZ-binding motifs in the diacylglycerol kinase family.

Zambo B, Gogl G, Morlet B, Eberling P, Negroni L, Moine H, Travé G

FEBS J. 2023 11 9;:

ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct.

Yayli G, Bernardini A, Mendoza Sanchez PK, Scheer E, Damilot M, Essabri K, Morlet B, Negroni L, Vincent SD, Timmers HTM, Tora L

Cell Rep. 2023 09 7;42(9):113099

Changes in social behavior with MAPK2 and KCTD13/CUL3 pathways alterations in two new outbred rat models for the 16p11.2 syndromes with autism spectrum disorders.

Martin Lorenzo S, Muniz Moreno MDM, Atas H, Pellen M, Nalesso V, Raffelsberger W, Prevost G, Lindner L, Birling MC, Menoret S, Tesson L, Negroni L, Concordet JP, Anegon I, Herault Y

Front Neurosci. 2023 07 3;17:1148683

A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatment.

Pelizzari-Raymundo D, Doultsinos D, Pineau R, Sauzay C, Koutsandreas T, Langlais T, Carlesso A, Gkotsi E, Negroni L, Avril T, Chatziioannou A, Chevet E, Eriksson LA, Guillory X

iScience. 2023 05 19;26(5):106687

The E2F4/p130 Repressor Complex Cooperates with Oncogenic ΔNp73α To Inhibit Gene Expression in Human Papillomavirus 38 E6/E7-Transformed Keratinocytes and in Cancer Cells.

Taverniti V, Krynska H, Venuti A, Straub ML, Sirand C, Lohmann E, Romero-Medina MC, Moro S, Robitaille A, Negroni L, Martinez-Zapien D, Masson M, Tommasino M, Zanier K

mSphere. 2023 03 8;:e0005623

Metalloprotease-mediated cleavage of CD95 Ligand.

Risso V, Thomas M, Guével B, Lavigne R, Com E, Martin S, Nivet M, Pineau C, Negroni L, Lafont É, Chevet É, Eriksson LA, Le Gallo M

FEBS J. 2023 01 24;:

Native holdup (nHU) to measure binding affinities from cell extracts.

Zambo B, Morlet B, Negroni L, Trave G, Gogl G

Sci Adv. 2022 12 21;8(51):eade3828

Quantitative fragmentomics allow affinity mapping of interactomes.

Gogl G, Zambo B, Kostmann C, Cousido-Siah A, Morlet B, Durbesson F, Negroni L, Eberling P, Jané P, Nominé Y, Zeke A, Østergaard S, Monsellier É, Vincentelli R, Travé G

Nat Commun. 2022 09 17;13(1):5472

Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.

Papaioannou A, Centonze F, Metais A, Maurel M, Negroni L, Gonzalez-Quiroz M, Mahdizadeh SJ, Svensson G, Zare E, Blondel A, Koong AC, Hetz C, Pedeux R, Tremblay ML, Eriksson LA, Chevet E

Life Sci Alliance. 2022 May;5(5):

Oxidative Transformation of Dihydroflavonols and Flavan-3-ols by Anthocyanidin Synthase from .

Zhang JR, Trossat-Magnin C, Bathany K, Negroni L, Delrot S, Chaudière J

Molecules. 2022 Feb 3;27(3):

Androgen receptor-mediated transcriptional repression targets cell plasticity in prostate cancer.

Erdmann É, Ould Madi Berthélémy P, Cottard F, Angel CZ, Schreyer E, Ye T, Morlet B, Negroni L, Kieffer B, Céraline J

Mol Oncol. 2021 Dec 17;:

Translation of GGC repeat expansions into a toxic polyglycine protein in NIID defines a novel class of human genetic disorders: the polyG diseases.

Boivin M, Deng J, Pfister V, Grandgirard E, Oulad-Abdelghani M, Morlet B, Ruffenach F, Negroni L, Koebel P, Jacob H, Riet F, Dijkstra AA, McFadden K, Clayton WA, Hong D, Miyahara H, Iwasaki Y, Sone J, Wang Z, Charlet-Berguerand N

Neuron. 2021 Apr 13;:

Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.

Coassolo S, Davidson G, Negroni L, Gambi G, Daujat S, Romier C, Davidson I

Nat Commun. 2021 Mar 19;12(1):1718

Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription.

Wang F, El-Saafin F, Ye T, Stierle M, Negroni L, Durik M, Fischer V, Devys D, Vincent SD, Tora L

Cell Death Differ. 2021 Mar 17;:

Reduced autophagy upon C9ORF72 loss synergizes with dipeptide repeat protein toxicity in G4C2 repeat expansion disorders.

Boivin M, Pfister V, Gaucherot A, Ruffenach F, Negroni L, Sellier C, Charlet-Berguerand N

EMBO J.. 2020 Jan 13;:e100574

Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA Polymerase II transcription.

El-Saafin F, Curry C, Ye T, Garnier JM, Kolb-Cheynel I, Stierle M, Downer NL, Dixon MP, Negroni L, Berger I, Thomas T, Voss AK, Dobyns W, Devys D, Tora L

Hum. Mol. Genet.. 2018 Apr 10;:

Integrated and Quantitative Proteomics of Human Tumors.

Yakkioui Y, Temel Y, Chevet E, Negroni L

Meth. Enzymol.. 2017 ;586:229-246

Mass Spectrometry of Mitochondrial Membrane Protein Complexes.

Negroni L, Zivy M, Lemaire C

Methods Mol. Biol.. 2017 ;1635:233-246

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