Protein mass spectra data analysis for clinical biomarker discovery: a global review.
Fiche publication
Date publication
mars 2011
Auteurs
Membres identifiés du Cancéropôle Est :
Mme TRUNTZER Caroline
Tous les auteurs :
Roy P, Truntzer C, Maucort-Boulch D, Jouve T, Molinari N
Lien Pubmed
Résumé
The identification of new diagnostic or prognostic biomarkers is one of the main aims of clinical cancer research. In recent years there has been a growing interest in using high throughput technologies for the detection of such biomarkers. In particular, mass spectrometry appears as an exciting tool with great potential. However, to extract any benefit from the massive potential of clinical proteomic studies, appropriate methods, improvement and validation are required. To better understand the key statistical points involved with such studies, this review presents the main data analysis steps of protein mass spectra data analysis, from the pre-processing of the data to the identification and validation of biomarkers.
Référence
Brief Bioinform. 2011 Mar;12(2):176-86