Targeting cancer with peptide aptamers.
Fiche publication
Date publication
juillet 2011
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GARRIDO Carmen, Dr GOBBO Jessica
Tous les auteurs :
Seigneuric R, Gobbo J, Colas P, Garrido C
Lien Pubmed
Résumé
A major endeavour in cancer chemotherapy is to develop agents that specifically target a biomolecule of interest. There are two main classes of targeting agents: small molecules and biologics. Among biologics (e.g.: antibodies), DNA, RNA but also peptide aptamers are relatively recent agents. Peptide aptamers are seldom described but represent attractive agents that can inhibit a growing panel of oncotargets including Heat Shock Proteins. Potential pitfalls and coming challenges towards successful clinical trials are presented such as optimizing the delivery of peptide aptamers thanks to Nanotechnology.
Référence
Oncotarget. 2011 Jul;2(7):557-61.