Advances in tenascin-C biology.

Fiche publication


Date publication

octobre 2011

Auteurs

Membres identifiés du Cancéropôle Est :
Dr LANGLOIS Benoît, Dr OREND Gertraud


Tous les auteurs :
Midwood KS, Hussenet T, Langlois B, Orend G

Résumé

Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerging evidence has demonstrated a vital role for tenascin-C in cardiac and arterial injury, tumor angiogenesis and metastasis, as well as in modulating stem cell behavior. Here we highlight the molecular mechanisms by which tenascin-C mediates these effects and discuss the implications of mis-regulated tenascin-C expression in driving disease pathology.

Référence

Cell Mol Life Sci. 2011 Oct;68(19):3175-99