Assessment of adrenal function in patients with acute hepatitis using serum free and total cortisol.
Fiche publication
Date publication
mai 2015
Auteurs
Membres identifiés du Cancéropôle Est :
Dr AGIN Arnaud, Pr DI MARTINO Vincent
Tous les auteurs :
Degand T, Monnet E, Durand F, Grandclement E, Ichai P, Borot S, Qualls CR, Agin A, Louvet A, Dumortier J, Francoz C, Dumoulin G, Di Martino V, Dorin R, Thevenot T
Lien Pubmed
Résumé
BACKGROUND: Adrenal dysfunction is frequently reported in severe acute hepatitis using serum total cortisol. AIMS: Because 90% of serum cortisol is bound to proteins that are altered during stress, we investigated the effect of decreased cortisol-binding proteins on serum total and free cortisol in severe acute hepatitis. METHODS: 43 severe and 31 non-severe acute hepatitis and 29 healthy controls were enrolled consecutively and studied prospectively. Baseline (T0) and cosyntropin-stimulated (T60) serum total and free cortisol concentrations were measured. RESULTS: T0 and T60 serum total cortisol did not differ significantly between severe, non-severe hepatitis and healthy controls. Conversely, serum free cortisol (T0p=0.012; T60p
Référence
Dig Liver Dis. 2015 May 22. pii: S1590-8658(15)00345-X