Dietary Resveratrol Modulates Metabolic Functions in Skeletal Muscle Cells.
Fiche publication
Date publication
avril 2012
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LANCON Allan, Dr LIZARD Gérard, Dr AIRES Virginie
Tous les auteurs :
Kaminski J, Lancon A, Tili E, Aires V, Demarquoy J, Lizard G, Michaille JJ I, Latruffe N
Lien Pubmed
Résumé
Resveratrol is one of the best known polyphenol. While its effect on endothelial blood vessel cells, cancer cells, inflammatory processes and neurodegenerative events is well documented, only little is established on the metabolic implication of this phytophenol, particularly on skeletal muscle cells. Here, we report the effect of resveratrol on mouse skeletal muscle cells (C2C12) by measurement of cell proliferation, expression of metabolic genes and their transcription factor dependency, and modulation of non-coding microRNA expression. Resveratrol slightly decreases cell proliferation, while it up regulates PGC-1 alpha a PPAR transcription factor co-activator involved in the control of metabolic genes. It also modulates microRNAs which are expressed in skeletal muscle cells and are involved in differentiation or contraction-relaxation. Results put forward new regulatory properties of resveratrol on skeletal muscles and highlight new potential applications of this molecule in muscle performances.
Référence
. 2012 Apr;20 1:398-401.