C-reactive protein predicts short-term mortality in patients with cirrhosis.
Fiche publication
Date publication
juin 2012
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DI MARTINO Vincent
Tous les auteurs :
Cervoni JP, Thevenot T, Weil D, Muel E, Barbot O, Sheppard F, Monnet E, Di Martino V
Lien Pubmed
Résumé
BACKGROUND & AIMS: We aimed at improving prediction of short-term mortality in cirrhotic inpatients by evaluating C-reactive protein (CRP) as a surrogate marker of systemic inflammatory response syndrome (SIRS). METHODS: One-hundred and forty-eight consecutive cirrhotic patients with Child-Pugh score >/= B8 and without hepatocellular carcinoma were prospectively included and followed for 182 days. The primary end point was 6-month survival. RESULTS: Main baseline characteristics were as follows: alcoholic liver disease in 88.5%; bacterial infection in 37%; hepatorenal syndrome in 7% of cases. CRP range was 1-240 mg/L (median 26 mg/L); 42 patients (28.4%) had SIRS as defined by ACCP/SCCM-criteria. CRP levels were higher in patients with SIRS (50 vs. 21 mg/L; p
Référence
J Hepatol. 2012 Jun;56(6):1299-304