Layer-by-Layer Enzymatic Platform for Stretched-Induced Reactive Release.
Fiche publication
Date publication
juillet 2012
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LAVALLE Philippe, Dr VOEGEL Jean-Claude, Pr SCHAAF Pierre, Dr MERTZ Damien
Tous les auteurs :
Vogt C, Mertz D, Benmlih K, Hemmerle J, Voegel JC, Schaaf P, Lavalle P
Lien Pubmed
Résumé
An original "all-in-one" platform combining polymers, enzymes, and enzymatic substrates in a unique film is designed. A polymeric barrier stratum prevents any contact between enzymes adsorbed on top of the film and substrates loaded in an underlying reservoir. Upon stretching of the film, a continuous diffusion of substrates through the barrier is triggered, followed by a catalytic reaction. This leads to the formation of products that are released from the film. This new platform acts as a stretch-induced reactive release system and emerges as an innovative concept in mechano-responsive materials.
Référence
. 2012 Jul;1(7):797-801.