Stretch-induced biodegradation of polyelectrolyte multilayer films for drug release.
Fiche publication
Date publication
septembre 2012
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LAVALLE Philippe, Dr VOEGEL Jean-Claude, Pr SCHAAF Pierre, Dr MERTZ Damien
Tous les auteurs :
Barthes J, Mertz D, Bach C, Metz-Boutigue MH, Senger B, Voegel JC, Schaaf P, Lavalle P
Lien Pubmed
Résumé
The design of stimuli-responsive polymer assemblies for the controlled release of bioactive molecules has raised considerable interest these two last decades. Herein, we report the design of mechanically responsive drug-releasing films made of polyelectrolyte multilayers. A layer-by-layer (LbL) reservoir containing biodegradable polyelectrolytes is capped with a mechanosensitive LbL barrier and responds to stretching by a total enzymatic degradation of the film. This strategy is successfully applied for the release in solution of an anticancer drug initially loaded within the architecture.
Référence
Langmuir. 2012 Sep 25;28(38):13550-4