Leucocytosis and thrombosis at diagnosis are associated with poor survival in polycythaemia vera: a population-based study of 327 patients.
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Date publication
janvier 2013
Auteurs
Membres identifiés du Cancéropôle Est :
Dr JOOSTE Valérie, Pr MAYNADIE Marc, Pr GIRODON François, Dr ROSSI Cédric
Tous les auteurs :
Bonicelli G, Abdulkarim K, Mounier M, Johansson P, Rossi C, Jooste V, Andreasson B, Maynadie M, Girodon F
Lien Pubmed
Résumé
Three hundred and twenty-seven patients from two population-based cohorts with an established diagnosis of polycythaemia vera were studied for prognostic risk factors for survival and leukaemia in a long-term survey. The relative survival (RS) was 72% and 46% at 10 and 20 years respectively, from the time of diagnosis. Multivariate analysis identified age >70 years, white blood cell count >13 x 10(9) /l and thrombo-embolism at diagnosis as independent risk factors. Patients with two or three of these factors had a 10 year RS of 26%, compared with 59% and 84% in patients with one and no risk factors, respectively. Age and leucocyte count are the main predicting factors for survival in polycythaemia vera.
Référence
Br J Haematol. 2013 Jan;160(2):251-4