[Vitamin D and breast cancer: is there a link?].
Fiche publication
Date publication
avril 2013
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MATHELIN Carole
Tous les auteurs :
Stoll F, Akladios CY, Mathelin C
Lien Pubmed
Résumé
OBJECTIVE: The aim of this review is to know the relationship between breast cancer and vitamin D, synthesised by skin or brought by food or supplementation. MATERIAL AND METHODS: The selected articles were extracted from the Pubmed database between 1998 and 2012. The keywords used were: "25-hydroxyvitamin D", "breast cancer recurrence", "breast cancer risk", "serum levels of vitamin D", "vitamin D intake". A total of 37 articles were selected. RESULTS: The sun exposure, via the skin vitamin D synthesis, is associated with a decreased risk of breast cancer. This decrease seems also likely for food contributions and an over 400IU per day vitamin D supplementation. An inverse relationship between plasma 25-hydroxyvitamin D (25-OH-D) level and breast cancer risk has been suggested. An increased 25-OH-D level seems associated with a decreased risk of breast cancer recurrence. CONCLUSION: Recommendations concerning a vitamin D supplementation could be established, but should be supported by additional studies.
Référence
Gynecol Obstet Fertil. 2013 Apr;41(4):242-50