Chronic low level metribuzin exposure induces metabolic alterations in rats.
Fiche publication
Date publication
mai 2013
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NARCE Michel
Tous les auteurs :
Chiali FZ, Merzouk H, Merzouk SA, Medjdoub A, Narce M
Lien Pubmed
Résumé
In this work we evaluated the in vivo effects of chronic metribuzin exposure at doses that mimic human exposure through diet. Male and female rats were fed a potato diet containing metribuzin at low doses (D1, 13 mg/kg or D2, 13 mg/kg) for 3 months. Plasma biochemical parameters (glucose, lipid, urea, creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST)), as well as lipid and protein contents, markers of oxidative stress in different organs (liver, adipose tissue, muscle, intestine) were determined. Our results showed that exposure to metribuzin induced a significant reduction in body weight, food intake and adverse alterations in biochemical parameters such as an increase in plasma glucose, triglyceride, urea, creatinine, ALT and AST levels. Total protein and lipid contents of organs were also altered with a concomitant presence of oxidative stress. In conclusion, chronic metribuzin exposure is associated to underfeeding and has adverse effects on organ functions leading to physiological impairment even at low concentrations. The nutritional management appears of the first importance. (C) 2013 Elsevier Inc. All rights reserved.
Référence
Pest Biochem Physiol. 2013 May-jun;106(1-2):38-44.