Prognostic score for recurrence after Whipple's pancreaticoduodenectomy for ampullary carcinomas; results of an AGEO retrospective multicenter cohort.
Fiche publication
Date publication
avril 2015
Journal
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Auteurs
Membres identifiés du Cancéropôle Est :
Mme POZET Astrid
Tous les auteurs :
Colussi O, Voron T, Pozet A, Hammel P, Sauvanet A, Bachet JB, Vaillant JC, Rougier P, Nordlinger B, Berger A, Coriat R, Dousset B, Malka D, André T, Paye F, Aparicio T, Locher C, Cojean Zeleck D, Tchinou L, Bonnetain F, Taieb J
Lien Pubmed
Résumé
Ampullary carcinoma (AC) is a relatively rare entity often managed as a biliopancreatic carcinoma. AC has a better prognosis than peri ampullary tumors after resection, but more than a third of patients relapse. Factors predictive of recurrence are controversial, mainly because the relevant studies are very small or also included non AC tumors. There are no guidelines on the use of adjuvant or neoadjuvant chemotherapy. The aim of this study was to identify prognostic factors for recurrence after AC resection in a large multicentric cohort, and to establish a simple, practical, predictive score for recurrence in order to guide multidisciplinary decisions.
Mots clés
Adult, Age Factors, Aged, Aged, 80 and over, Ampulla of Vater, Antineoplastic Combined Chemotherapy Protocols, administration & dosage, Carcinoma, pathology, Chemoradiotherapy, Adjuvant, Chemotherapy, Adjuvant, Common Bile Duct Neoplasms, pathology, Deoxycytidine, administration & dosage, Disease-Free Survival, Female, Fluorouracil, administration & dosage, Health Status, Humans, Leucovorin, administration & dosage, Male, Middle Aged, Neoplasm Grading, Neoplasm Recurrence, Local, Neoplasm Staging, Organoplatinum Compounds, administration & dosage, Pancreaticoduodenectomy, Retrospective Studies, Risk Assessment, methods, Survival Rate
Référence
Eur J Surg Oncol. 2015 Apr;41(4):520-6