Possible mediators of metabolic endotoxemia in women with obesity and women with obesity-diabetes in The Gambia.

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Date publication

août 2022

Journal

International journal of obesity (2005)

Auteurs

Membres identifiés du Cancéropôle Est :
Dr LAGROST Laurent


Tous les auteurs :
Jobe M, Agbla SC, Todorcevic M, Darboe B, Danso E, de Barros JP, Lagrost L, Karpe F, Prentice AM

Résumé

Translocation of bacterial debris from the gut causes metabolic endotoxemia (ME) that results in insulin resistance, and may be on the causal pathway to obesity-related type 2 diabetes. To guide interventions against ME we tested two hypothesised mechanisms for lipopolysaccharide (LPS) ingress: a leaky gut and chylomicron-associated transfer following a high-fat meal.

Référence

Int J Obes (Lond). 2022 08 6;: