An update on drug-drug interactions associated with proton pump inhibitors.
Fiche publication
Date publication
juillet 2022
Journal
Expert opinion on drug metabolism & toxicology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BARDOU Marc
Tous les auteurs :
Ben Ghezala I, Luu M, Bardou M
Lien Pubmed
Résumé
Proton pump inhibitors (PPIs) block the gastric H/K-ATPase, therefore inhibiting acid gastric secretion, leading to an increased pH (>4). They account for an extremely high number of prescriptions worldwide. Numerous drug-drug interactions have been described with PPIs, but all the described interactions do not have clinical significance.
Mots clés
Antiplatelet agents, CYP2C19, antibiotics, antidiabetics, antifungal, gastroesophageal reflux, helicobacter, oncology drugs, peptic ulcer
Référence
Expert Opin Drug Metab Toxicol. 2022 07 4;: