DNA methylation profiles after ART during human lifespan: a systematic review and meta-analysis.
Fiche publication
Date publication
mars 2022
Journal
Human reproduction update
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FAUQUE Patricia
Tous les auteurs :
Barberet J, Ducreux B, Guilleman M, Simon E, Bruno C, Fauque P
Lien Pubmed
Résumé
The many manipulations and processes used in ART coincide with the timing of epigenetic reprogramming and imprinting during female gametogenesis and pre-implantation embryo development, leading to concerns that the actual ART could negatively affect epigenetic reprogramming and imprinting in gametes and early embryos. A growing body of literature suggests that ART may affect epigenetic marks, such as DNA methylation, in the fetus and placenta. Potentially, this may be responsible later in life for the increased risk of adverse outcomes associated with ART. Unfortunately, the conclusions are inconsistent and, despite the increasing usage of ART, its safety at the epigenetic level is still not established.
Mots clés
ART, DNA methylation, ICSI, IVF, imprinted gene, meta-analysis, systematic review
Référence
Hum Reprod Update. 2022 Mar 8;: