Adverse Mechanical Ventilation and Pneumococcal Pneumonia Induce Immune and Mitochondrial Dysfunctions Mitigated by Mesenchymal Stem Cells in Rabbits.
Fiche publication
Date publication
décembre 2021
Journal
Anesthesiology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BENSOUSSAN Danièle, Mme BATAILLE Amandine, Dr REPPEL Loïc
Tous les auteurs :
Blot M, Jacquier M, Pauchard LA, Rebaud C, Marlin C, Hamelle C, Bataille A, Croisier D, Thomas C, Jalil A, Mirfendereski H, Piroth L, Chavanet P, Bensoussan D, Laroye C, Reppel L, Charles PE
Lien Pubmed
Résumé
Mechanical ventilation for pneumonia may contribute to lung injury due to factors that include mitochondrial dysfunction, and mesenchymal stem cells may attenuate injury. This study hypothesized that mechanical ventilation induces immune and mitochondrial dysfunction, with or without pneumococcal pneumonia, that could be mitigated by mesenchymal stem cells alone or combined with antibiotics.
Référence
Anesthesiology. 2021 Dec 29;: