Differences in expression rather than methylation at placenta-specific imprinted loci is associated with intrauterine growth restriction.

Fiche publication


Date publication

février 2019

Journal

Clinical epigenetics

Auteurs

Membres identifiés du Cancéropôle Est :
Pr FAUQUE Patricia


Tous les auteurs :
Monteagudo-Sánchez A, Sánchez-Delgado M, Mora JRH, Santamaría NT, Gratacós E, Esteller M, de Heredia ML, Nunes V, Choux C, Fauque P, de Nanclares GP, Anton L, Elovitz MA, Iglesias-Platas I, Monk D

Résumé

Genome-wide studies have begun to link subtle variations in both allelic DNA methylation and parent-of-origin genetic effects with early development. Numerous reports have highlighted that the placenta plays a critical role in coordinating fetal growth, with many key functions regulated by genomic imprinting. With the recent description of wide-spread polymorphic placenta-specific imprinting, the molecular mechanisms leading to this curious polymorphic epigenetic phenomenon is unknown, as is their involvement in pregnancies complications.

Mots clés

DNA methylation, Epigenetics, Imprinting, Placenta

Référence

Clin Epigenetics. 2019 02 26;11(1):35