Differences in expression rather than methylation at placenta-specific imprinted loci is associated with intrauterine growth restriction.
Fiche publication
Date publication
février 2019
Journal
Clinical epigenetics
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FAUQUE Patricia
Tous les auteurs :
Monteagudo-Sánchez A, Sánchez-Delgado M, Mora JRH, Santamaría NT, Gratacós E, Esteller M, de Heredia ML, Nunes V, Choux C, Fauque P, de Nanclares GP, Anton L, Elovitz MA, Iglesias-Platas I, Monk D
Lien Pubmed
Résumé
Genome-wide studies have begun to link subtle variations in both allelic DNA methylation and parent-of-origin genetic effects with early development. Numerous reports have highlighted that the placenta plays a critical role in coordinating fetal growth, with many key functions regulated by genomic imprinting. With the recent description of wide-spread polymorphic placenta-specific imprinting, the molecular mechanisms leading to this curious polymorphic epigenetic phenomenon is unknown, as is their involvement in pregnancies complications.
Mots clés
DNA methylation, Epigenetics, Imprinting, Placenta
Référence
Clin Epigenetics. 2019 02 26;11(1):35