Reproductive technologies, female infertility, and the risk of imprinting-related disorders.
Fiche publication
Date publication
décembre 2020
Journal
Clinical epigenetics
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FAUQUE Patricia
Tous les auteurs :
Fauque P, De Mouzon J, Devaux A, Epelboin S, Gervoise-Boyer MJ, Levy R, Valentin M, Viot G, Bergère A, De Vienne C, Jonveaux P, Pessione F
Lien Pubmed
Résumé
Epidemiological studies suggest that singletons born from assisted reproductive technologies (ART) have a high risk of adverse perinatal outcomes, specifically for imprinting disorders. Because ART processes take place at times when epigenetic reprogramming/imprinting are occurring, there is concern that ART can affect genomic imprints. However, little is currently known about the risk of imprinting defects according to the type of ART or the type of underlying female infertility. From the French national health database, a cohort of 3,501,495 singletons born over a 5-year period (2013-2017) following fresh embryo or frozen embryo transfers (fresh-ET or FET from in vitro fertilization), intrauterine insemination, or natural conception was followed up to early childhood. Based on clinical features, several syndromes/diseases involving imprinted genes were monitored. The effects of ART conception and the underlying cause of female infertility were assessed.
Mots clés
Assisted reproductive technologies, Children, Epigenetic diseases, Female infertility, Singletons
Référence
Clin Epigenetics. 2020 12 11;12(1):191