Fibrotic extracellular matrix induces release of extracellular vesicles with pro-fibrotic miRNA from fibrocytes.
Fiche publication
Date publication
avril 2021
Journal
Thorax
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BELLAYE Pierre-Simon
Tous les auteurs :
Sato S, Chong SG, Upagupta C, Yanagihara T, Saito T, Shimbori C, Bellaye PS, Nishioka Y, Kolb MR
Lien Pubmed
Résumé
Extracellular vesicles (EVs) are small lipid vesicles, and EV-coupled microRNAs (miRNAs) are important modulators of biological processes. Fibrocytes are circulating bone marrow-derived cells that migrate into the injured lungs and contribute to fibrogenesis. The question of whether EV-coupled miRNAs derived from fibrocytes are able to regulate pulmonary fibrosis has not been addressed yet.
Mots clés
idiopathic pulmonary fibrosis
Référence
Thorax. 2021 Apr 15;: