The NANOTUMOR consortium - towards the Tumor Cell Atlas.
Fiche publication
Date publication
février 2021
Journal
Biology of the cell
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GOETZ Jacky, Dr HAMICHE Ali, Dr RONDE Philippe, Dr SCHULTZ Patrick, Dr SUMARA Izabela, Dr MENDOZA Manuel, Dr HYENNE Vincent
Tous les auteurs :
Colin F, Schauer K, Hamiche A, Martineau P, Borg JP, Bednar J, Bertolin G, Camoin L, Collette Y, Dimitrov S, Fournier I, Hyenne V, Mendoza-Parra MA, Morelli X, Rondé P, Sumara I, Tramier M, Schultz P, Goetz JG
Lien Pubmed
Résumé
Cancer is a multi-step disease where an initital tumor progresses through critical steps shaping, in most cases, life-threatening secondary foci called metastases. The oncogenic cascade involves genetic, epigenetic, signaling pathways, intracellular trafficking and/or metabolic alterations within cancer cells. In addition, pre-malignant and malignant cells orchestrate complex and dynamic interactions with non-malignant cells and acellular matricial components or secreted factors within the tumor microenvironment that is instrumental in the progression of the disease. As our aptitude to effectively treat cancer mostly depends on our ability to decipher, properly diagnose and impede cancer progression and metastasis formation, full characterization of molecular complexes and cellular processes at play along the metastasis cascade is crucial. For many years, the scientific community lacked adapted imaging and molecular technologies to accurately dissect, at the highest resolution possible, tumor and stromal cells behavior within their natural microenvironment. In that context, the NANOTUMOR consortium is a French national multi-disciplinary workforce which aims at a providing a multi-scale characterization of the oncogenic cascade, from the atomic level to the dynamic organization of the cell in response to genetic mutations, environmental changes or epigenetic modifications. Ultimately, this program aims at identifying new therapeutic targets using innovative drug design. This article is protected by copyright. All rights reserved.
Référence
Biol Cell. 2021 Feb 7;: