Modulation of CD4 T Cell Response According to Tumor Cytokine Microenvironment.
Fiche publication
Date publication
janvier 2021
Journal
Cancers
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VEGRAN Frédérique, Dr BRUCHARD Mélanie
Tous les auteurs :
Accogli T, Bruchard M, Végran F
Lien Pubmed
Résumé
The advancement of knowledge on tumor biology over the past decades has demonstrated a close link between tumor cells and cells of the immune system. In this context, cytokines have a major role because they act as intermediaries in the communication into the tumor bed. Cytokines play an important role in the homeostasis of innate and adaptive immunity. In particular, they participate in the differentiation of CD4 T lymphocytes. These cells play essential functions in the anti-tumor immune response but can also be corrupted by tumors. The differentiation of naïve CD4 T cells depends on the cytokine environment in which they are activated. Additionally, at the tumor site, their activity can also be modulated according to the cytokines of the tumor microenvironment. Thus, polarized CD4 T lymphocytes can see their phenotype evolve, demonstrating functional plasticity. Knowledge of the impact of these cytokines on the functions of CD4 T cells is currently a source of innovation, for therapeutic purposes. In this review, we discuss the impact of the major cytokines present in tumors on CD4 T cells. In addition, we summarize the main therapeutic strategies that can modulate the CD4 response through their impact on cytokine production.
Mots clés
CD4, cancer, cytokines, immunotherapy
Référence
Cancers (Basel). 2021 Jan 20;13(3):