Dual Cherenkov Radiation-induced Near-Infrared Luminescence Imaging and Photodynamic Therapy towards Tumor Resection.
Fiche publication
Date publication
juillet 2020
Journal
Journal of medicinal chemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr COLLIN Bertrand, Dr DECREAU Richard, Dr BELLAYE Pierre-Simon
Tous les auteurs :
Lioret V, Bellaye PS, Arnould C, Collin B, Decreau RA
Lien Pubmed
Résumé
Cherenkov Radiation (CR), the blue light seen in nuclear reactors is emitted by some radiopharmaceuticals. This study showed that 1) a portion of CR could be transferred in the region of the optical spectrum where biological tissues are most transparent: as a result, upon radiance amplification in the NIR window, the detection of light could occur twice deeper in tissues than during classical Cherenkov Luminescence Imaging (CLI). 2) Cherenkov-Photodynamic Therapy (CR-PDT) on cells could be achieved under conditions mimicking unlimited depth using CR embarked light source, which is unlike standard Photodynamic Therapy (PDT) where light penetration depth is limited in biological tissues. Both results are of utmost importance for simultaneous applications in tumor resection and post-resection treatment of remaining un-resected margins, thanks to a molecular construct designed to raise its light collection efficiency (i.e. CR Energy Transfer (CRET)) by conjugation with multiple CR-absorbing (water-soluble) antenna followed by intramolecular-FRET/TBET energy transfers.
Référence
J. Med. Chem.. 2020 Jul 24;: