Sonic hedgehog signalling as a potential endobronchial biomarker in COPD.

Fiche publication


Date publication

août 2020

Journal

Respiratory research

Auteurs

Membres identifiés du Cancéropôle Est :
Pr POLETTE Myriam, Dr DORMOY Valerian


Tous les auteurs :
Ancel J, Belgacemi R, Perotin JM, Diabasana Z, Dury S, Dewolf M, Bonnomet A, Lalun N, Birembaut P, Polette M, Deslée G, Dormoy V

Résumé

The hedgehog (HH) pathway has been associated with chronic obstructive pulmonary disease (COPD) in genome-wide association studies and recent studies suggest that HH signalling could be altered in COPD. We therefore used minimally invasive endobronchial procedures to assess activation of the HH pathway including the main transcription factor, Gli2, and the ligand, Sonic HH (Shh).

Mots clés

Airway epithelial cells, Bronchoscopy, Chronic obstructive pulmonary disease, Hedgehog signalling pathway

Référence

Respir. Res.. 2020 Aug 7;21(1):207