IBiSS, a versatile and interactive tool for integrated sequence and 3D structure analysis of large macromolecular complexes.
Fiche publication
Date publication
octobre 2015
Journal
Bioinformatics (Oxford, England)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr KLAHOLZ Bruno
Tous les auteurs :
Beinsteiner B, Michalon J, Klaholz BP
Lien Pubmed
Résumé
In the past few years, an increasing number of crystal and cryo electron microscopy (cryo-EM) structures of large macromolecular complexes, such as the ribosome or the RNA polymerase, have become available from various species. These multi-subunit complexes can be difficult to analyze at the level of amino acid sequence in combination with the 3D structural organization of the complex. Therefore, novel tools for simultaneous analysis of structure and sequence information of complex assemblies are required to better understand the basis of molecular mechanisms and their functional implications.
Mots clés
Amino Acids, chemistry, Cryoelectron Microscopy, methods, DNA-Directed RNA Polymerases, chemistry, Databases, Protein, Humans, Imaging, Three-Dimensional, Macromolecular Substances, chemistry, Models, Molecular, Nucleosomes, chemistry, Photosystem I Protein Complex, chemistry, Photosystem II Protein Complex, chemistry, Proteasome Endopeptidase Complex, chemistry, Proteins, chemistry, Ribosomes, chemistry, Software, User-Computer Interface
Référence
Bioinformatics. 2015 Oct 15;31(20):3339-44