Radiation-induced CD8 T-lymphocyte Apoptosis as a Predictor of Breast Fibrosis After Radiotherapy: Results of the Prospective Multicenter French Trial.
Fiche publication
Date publication
décembre 2015
Journal
EBioMedicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NOEL Georges, Dr PEIGNAUX Karine
Tous les auteurs :
Azria D, Riou O, Castan F, Nguyen TD, Peignaux K, Lemanski C, Lagrange JL, Kirova Y, Lartigau E, Belkacemi Y, Bourgier C, Rivera S, Noël G, Clippe S, Mornex F, Hennequin C, Kramar A, Gourgou S, Pèlegrin A, Fenoglietto P, Ozsahin EM
Lien Pubmed
Résumé
Monocentric cohorts suggested that radiation-induced CD8 T-lymphocyte apoptosis (RILA) can predict late toxicity after curative intent radiotherapy (RT). We assessed the role of RILA as a predictor of breast fibrosis (bf +) after adjuvant breast RT in a prospective multicenter trial.
Mots clés
Adult, Aged, Aged, 80 and over, Apoptosis, radiation effects, Biomarkers, Tumor, Breast Neoplasms, complications, CD8-Positive T-Lymphocytes, immunology, Female, Fibrocystic Breast Disease, diagnosis, Fibrosis, Humans, Incidence, Middle Aged, Neoplasm Grading, Neoplasm Staging, Prognosis, Proportional Hazards Models, Radiotherapy, Adjuvant, adverse effects, Recurrence, Risk Factors
Référence
EBioMedicine. 2015 Dec;2(12):1965-73