Functional roles of GDF15 in modulating microenvironment to promote carcinogenesis.
Fiche publication
Date publication
avril 2020
Journal
Biochimica et biophysica acta. Molecular basis of disease
Auteurs
Membres identifiés du Cancéropôle Est :
Pr COTTIN Yves, Pr VERGELY Catherine
Tous les auteurs :
Rochette L, Méloux A, Zeller M, Cottin Y, Vergely C
Lien Pubmed
Résumé
Obesity and related metabolic dysregulation are risk factors for many types of cancer. The interactions between a developing tumor and its microenvironment are known to implicate a complex "crosstalk" among the factors produced by the population of cells. Among these factors, Growth and differentiation factor 15 (GDF15) has a functional role in cancer. GDF15 expression is induced in response to the conditions associated with cellular stress and diseases. The GDF15 receptor, a member of the glial-cell-derived neurotropic factor family (GDNF), is a GDNF family receptor α-like (GFRAL) protein. GDF15 induces pro-angiogenic effects in tumors. However, GDF15 could affect tumorigenesis both positively and negatively. With a better understanding of the upstream disease pathways reflected by GDF15, new treatment targets may emerge.
Mots clés
Angiogenesis, Cancer, GDF15, Obesity
Référence
Biochim Biophys Acta Mol Basis Dis. 2020 Apr 15;:165798