Dyslipidemia in Type 1 Diabetes: A Masked Danger.
Fiche publication
Date publication
mars 2020
Journal
Trends in endocrinology and metabolism: TEM
Lien Pubmed
Résumé
Type 1 diabetes (T1D) patients show lipid disorders which are likely to play a role in their increased cardiovascular (CV) disease risk. Quantitative abnormalities of lipoproteins are noted in T1D with poor glycemic control. In T1D with optimal glycemic control, triglycerides and LDL-cholesterol are normal or slightly decreased whereas HDL-cholesterol is normal or slightly increased. T1D patients, even with good glycemic control, show several qualitative and functional abnormalities of lipoproteins that are potentially atherogenic. An association between these abnormalities and CV disease risk has been reported in recent studies. Although the mechanisms underlying T1D dyslipidemia remain unclear, the subcutaneous route of insulin administration, that is responsible for peripheral hyperinsulinemia, is likely to be an important factor.
Mots clés
cardiovascular, insulin, lipids, lipoproteins, type 1 diabetes
Référence
Trends Endocrinol. Metab.. 2020 Mar 2;: