Spirulina reduces diet-induced obesity through downregulation of lipogenic genes expression in .
Fiche publication
Date publication
mars 2020
Journal
Archives of physiology and biochemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Pr KAHN Naim, Dr HICHAMI Aziz
Tous les auteurs :
Saidi H, Bounihi A, Bouazza A, Hichami A, Koceir EHA, Khan NA
Lien Pubmed
Résumé
The present study evaluates the protective effect of spirulina against diet-induced obesity and metabolic disorders in , an animal model of metabolic syndrome. lives on a low-energy diet, in order to remain healthy. However, under a standard laboratory chow diet (SLCD), this animal exhibits insulin resistance, which occurs as a result of obesity. was maintained on SLCD, in order to evaluate the effect of spirulina on obesity development with a particular focus on glucose and lipid metabolism, as well as the mRNA expression of some pro-inflammatory cytokines. After 12 weeks of treatment with spirulina, there was a significant reduction in body weight gain, plasma glucose, insulin and triglyceride levels. There was also a significant reduction in the mRNA expression of genes involved in lipogenesis and inflammation. Spirulina improved insulin sensitivity, glucose and lipid metabolism. These findings highlight the positive effect of spirulina on weight maintenance.
Mots clés
Psammomys obesus, Spirulina, insulin-resistance, lipogenesis, obesity
Référence
Arch. Physiol. Biochem.. 2020 Mar 24;:1-9