The potential of cholesteryl ester transfer protein as a therapeutic target.
Fiche publication
Date publication
janvier 2016
Journal
Expert opinion on therapeutic targets
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LAGROST Laurent, Pr MASSON David
Tous les auteurs :
Gautier T, Masson D, Lagrost L
Lien Pubmed
Résumé
Over recent decades, attempts to ascertain the pro-atherogenic nature of plasma cholesteryl ester transfer protein (CETP) and to establish the relevance of its pharmacological blockade as a promising high density lipoproteins-raising and anti-atherogenic therapy have been disappointing.
Mots clés
Animals, Atherosclerosis, etiology, Cardiovascular Diseases, etiology, Cholesterol Ester Transfer Proteins, antagonists & inhibitors, Drug Design, Humans, Molecular Targeted Therapy, Patient Selection, Risk Factors
Référence
Expert Opin. Ther. Targets. 2016 ;20(1):47-59