Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD.
Fiche publication
Date publication
janvier 2020
Journal
EBioMedicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr POLETTE Myriam, Dr DORMOY Valerian
Tous les auteurs :
Belgacemi R, Luczka E, Ancel J, Diabasana Z, Perotin JM, Germain A, Lalun N, Birembaut P, Dubernard X, Mérol JC, Delepine G, Polette M, Deslée G, Dormoy V
Lien Pubmed
Résumé
Hedgehog (HH) pathway is constantly under scrutiny in the context of organ development. Lung morphogenesis requires HH signalling which participates thereafter to the pulmonary homeostasis by regulating epithelial cell quiescence and repair. Since epithelial remodelling is a hallmark of Chronic Obstructive Pulmonary Disease (COPD), we investigated whether the main molecular actors of HH pathway participate to airway epithelial cell differentiation and we analysed their alterations in COPD patients.
Mots clés
Airway epithelial cells, Chronic obstructive pulmonary disease, Cilia, Differentiation, Hedgehog
Référence
EBioMedicine. 2020 Jan;51:102572