Hemostatic, inflammatory, and oxidative markers in pesticide user farmers.
Fiche publication
Date publication
janvier 2016
Journal
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NARCE Michel
Tous les auteurs :
Madani FZ, Hafida M, Merzouk SA, Loukidi B, Taouli K, Narce M
Lien Pubmed
Résumé
The aim of this work was to investigate inflammatory, oxidative, and thrombotic parameters as biomarkers in farmers exposed to pesticides. Fifty farmers using chemical pesticides and 60 unexposed control men participated in this study. The Mediterranean diet compliance, the duration of pesticide use, and personal protection for pesticides handling were recorded using self-administered questionnaires. Serum biochemical parameters, oxidant/antioxidant, inflammatory, and thrombosis markers were determined. Our findings showed oxidative stress reflected by an increase in malondialdehyde, carbonyl proteins and superoxide anion levels and a decrease in vitamins C and E, glutathione, catalase, and superoxide dismutase activities in farmers. Serum C-reactive protein, prothrombin, and fibrinogen levels were enhanced in these farmers. In conclusion, inflammation, oxidative stress, and metabolic perturbations reflected the possibility of the effects of pesticides to farmers.
Mots clés
Adult, Ascorbic Acid, blood, Biomarkers, blood, C-Reactive Protein, metabolism, Catalase, blood, Farmers, Fibrinogen, metabolism, Glutathione, blood, Hemostatics, blood, Humans, Inflammation, blood, Logistic Models, Male, Malondialdehyde, blood, Middle Aged, Occupational Exposure, adverse effects, Oxidation-Reduction, drug effects, Oxidative Stress, drug effects, Pesticides, poisoning, Protein Carbonylation, Prothrombin, metabolism, Superoxide Dismutase, blood, Superoxides, blood, Surveys and Questionnaires, Vitamin E, blood
Référence
Biomarkers. 2016 ;21(2):138-45