Major changes in the sphingophospholipidome of HDL in non-diabetic patients with metabolic syndrome.
Fiche publication
Date publication
mars 2016
Journal
Atherosclerosis
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DUVILLARD Laurence, Pr PETIT Jean-Michel, Pr VERGES Bruno, Dr PAIS DE BARROS Jean-Paul
Tous les auteurs :
Denimal D, Nguyen A, Pais de Barros JP, Bouillet B, Petit JM, Vergès B, Duvillard L
Lien Pubmed
Résumé
Phospholipids and sphingolipids play a critical role in the protective effects of HDL against atherosclerosis. These properties are impaired in patients with metabolic syndrome, before the development of diabetes. We thus investigated whether HDL from patients with metabolic syndrome but normal fasting glycaemia present abnormalities in their sphingophospholipid profile.
Mots clés
Adult, Biomarkers, blood, Case-Control Studies, Chromatography, Liquid, Female, Humans, Lipoproteins, HDL, blood, Male, Metabolic Syndrome X, blood, Middle Aged, Obesity, complications, Phospholipids, blood, Sphingolipids, blood, Tandem Mass Spectrometry
Référence
Atherosclerosis. 2016 Mar;246:106-14